Technetium (99mTc) nofetumomab merpentan
 | |
| Monoclonal antibody | |
|---|---|
| Type | Fab fragment |
| Source | Mouse |
| Clinical data | |
| Trade names | Verluma |
| ATC code | none |
| Pharmacokinetic data | |
| Biological half-life | 10.5 hours |
| Excretion | renal (64%) |
| Identifiers | |
| CAS Number |
165942-79-0  |
| ChemSpider | none |
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Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]
Nofetumomab
Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]
It is the Fab part of murine MAb NR-LU-10.[6]
Merpentan
The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]
Phenthioate
Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]
References
- ↑ Straka, MR; Joyce, JM; Myers, DT (2000). "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer". Clinical nuclear medicine. 25 (1): 54–5. doi:10.1097/00003072-200001000-00013. PMID 10634533.
- ↑ Breitz, HB; Tyler, A; Bjorn, MJ; Lesley, T; Weiden, PL (1997). "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy". Clinical nuclear medicine. 22 (9): 615–20. doi:10.1097/00003072-199709000-00007. PMID 9298295.
- ↑ WHO Drug Information
- ↑ Molecular Biology of B Cells. p533
- ↑ technetium (99mTc) nofetumomab merpentan (TAB-711)
- 1 2 Monoclonal Antibody Radionuclide Test Kits
- ↑ Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A