Tabtoxinine β-lactam
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| Names | |
|---|---|
| IUPAC name
(S)-2-Amino-4-((S)-3-hydroxy-2-oxoazetidin-3-yl)butanoic acid | |
| Other names
(αS,3S)-α-Amino-3-hydroxy-2-oxo-3-azetidinebutanoic acid; (−)-Tabtoxinine β-lactam | |
| Identifiers | |
65709-93-5  | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 24751854 |
| PubChem | 3035052 |
| |
| |
| Properties | |
| C7H12N2O4 | |
| Molar mass | 188.18 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tabtoxinine β-lactam is a monobactam antibiotic derived from tabtoxin. Unlike other β-lactam antibiotics, which inhibit penicillin-binding proteins, tabtoxinine β-lactam inhibits glutamine synthetase.[1]
References
- ↑ Thomas, M. D.; Langston-Unkefer, P. J.; Uchytil, T. F.; Durbin, R. D. (1983). "Inhibition of Glutamine Synthetase from Pea by Tabtoxinine-β-lactam". Plant Physiology. 71 (4): 912–915. doi:10.1104/pp.71.4.912. PMC 1066143
. PMID 16662928.
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