TRNA pseudouridine13 synthase
| TRNA pseudouridine13 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.27 | ||||||||
| CAS number | 430429-15-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA pseudouridine13 synthase (EC 5.4.99.27, TruD, YgbO, tRNA PSI13 synthase, RNA:PSI-synthase Pus7p, Pus7p, RNA:pseudouridine-synthase Pus7p, Pus7 protein) is an enzyme with systematic name tRNA-uridine13 uracil mutase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- tRNA uridine13 tRNA pseudouridine13
Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA.
References
- ↑ Ericsson, U.B.; Nordlund, P.; Hallberg, B.M. (2004). "X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold". FEBS Lett. 565: 59–64. doi:10.1016/j.febslet.2004.03.085. PMID 15135053.
- ↑ Chan, C.M.; Huang, R.H. (2009). "Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases". Arch. Biochem. Biophys. 489: 15–19. doi:10.1016/j.abb.2009.07.023. PMID 19664587.
- ↑ Kaya, Y.; Ofengand, J. (2003). "A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya". RNA. 9: 711–721. doi:10.1261/rna.5230603. PMID 12756329.
- ↑ Behm-Ansmant, I.; Urban, A.; Ma, X.; Yu, Y.T.; Motorin, Y.; Branlant, C. (2003). "The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs". RNA. 9: 1371–1382. doi:10.1261/rna.5520403. PMID 14561887.
- ↑ Urban, A.; Behm-Ansmant, I.; Branlant, C.; Motorin, Y. (2009). "RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p". J. Biol. Chem. 284: 5845–5858. doi:10.1074/jbc.m807986200. PMID 19114708.
External links
- TRNA pseudouridine13 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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