TRIM33

TRIM33
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases TRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33
External IDs MGI: 2137357 HomoloGene: 9296 GeneCards: TRIM33
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

51592

94093

Ensembl

ENSG00000197323

ENSMUSG00000033014

UniProt

Q9UPN9

Q99PP7

RefSeq (mRNA)

NM_015906
NM_033020

NM_001079830
NM_053170

RefSeq (protein)

NP_056990.3
NP_148980.2

NP_001073299.1
NP_444400.2

Location (UCSC) Chr 1: 114.39 – 114.51 Mb Chr 3: 103.28 – 103.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.[3][4]

The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.[3]

Structure

The protein is a member of the tripartite motif family.[5] This motif includes three zinc-binding domains:

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.[3]

Interactions

TRIM33 has been shown to interact with TRIM24.[6]

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.[7] TRIM33 regulates also the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells. [8] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.[9]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 3 "Entrez Gene: TRIM33 tripartite motif-containing 33".
  4. ↑ Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H; You; Stadler; Galien; Lallemand; Koken; Mattei; Ganser; Chambon; Losson; De Thé (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127.
  5. ↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A; Meroni; Fantozzi; Merla; Cairo; Luzi; Riganelli; Zanaria; Messali; Cainarca; Guffanti; Minucci; Pelicci; Ballabio (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245Freely accessible. PMID 11331580.
  6. ↑ Peng, Hongzhuang; Feldman Irina; Rauscher Frank J (Jul 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. England. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. ISSN 0022-2836. PMID 12096914.
  7. ↑ Aucagne, R; Droin, N; Paggetti, J; Lagrange, B; Largeot, A; Hammann, A; Bataille, A; Martin, L; Yan, K. P.; Fenaux, P; Losson, R; Solary, E; Bastie, J. N.; Delva, L (2011). "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". Journal of Clinical Investigation. 121 (6): 2361–70. doi:10.1172/JCI45213. PMC 3104753Freely accessible. PMID 21537084.
  8. ↑ Quéré, R; Saint-Paul, L; Carmignac, V; Martin, R; Chrétien, M; Largeot, A; Hammann, A; Pais de Barros, J. P.; Bastie, J. N.; Delva, L (2014). "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proc Natl Acad Sci U S A. 111 (29): 10592–7. doi:10.1073/pnas.1405546111. PMC 4115559Freely accessible. PMID 25002492.
  9. ↑ Wang, E; Kawaoka, S; Roe, J. S.; Shi, J; Hohmann, A. F.; Xu, Y; Bhagwat, A. S.; Suzuki, Y; Kinney, J. B.; Vakoc, C. R. (2015). "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife. 4. doi:10.7554/eLife.06377. PMID 25919951.

Further reading

  • Venturini L, You J, Stadler M, et al. (1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127. 
  • Klugbauer S, Rabes HM; Rabes (1999). "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas". Oncogene. 18 (30): 4388–93. doi:10.1038/sj.onc.1202824. PMID 10439047. 
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851. 
  • Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245Freely accessible. PMID 11331580. 
  • Peng H, Feldman I, Rauscher FJ; Feldman; Rauscher Fj (2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914. 
  • Yoon HG, Chan DW, Reynolds AB, et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Dupont S, Zacchigna L, Cordenonsi M, et al. (2005). "Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase". Cell. 121 (1): 87–99. doi:10.1016/j.cell.2005.01.033. PMID 15820681. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414. 
  • He W, Dorn DC, Erdjument-Bromage H, et al. (2006). "Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway". Cell. 125 (5): 929–41. doi:10.1016/j.cell.2006.03.045. PMID 16751102. 

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