Szilard Voros

Szilard Voros
Born	Budapest, Hungary
Education	University of Alabama at Birmingham (Residency), University Medical School of Pécs (M.D.)
Occupation	Cardiologist, Scientist

Szilard Voros is a Hungarian-born American cardiologist and globally renowned leading research scientist in advanced cardiovascular imaging, biomarkers, lipoprotein metabolism and genomics. He currently serves as an Associate Professor of Medicine/Cardiology and Radiology, and Director of Advanced Cardiovascular MR and CT Research at the Department of Radiology and Cardiology at Stony Brook University Medical Center, State University of New York. He previously served as the Chief Scientific Officer, Chief of Cardiovascular Prevention, and Medical Director of Cardiac MR and CT at Piedmont Hospital in Atlanta, Georgia, and as a Clinical Associate Professor of Medicine at the Medical College of Georgia. He is a founding member and Fellow of the Society of Cardiovascular Computed Tomography (FSCCT), Fellow of the American College of Cardiology (FACC) and Fellow of the American Heart Association (FAHA).

Biography

In 1996, as a summa cum laude graduate of the University Medical School of Pécs in Hungary, Voros moved to the United States to pursue his Internship and Residency in Internal Medicine at the University of Alabama at Birmingham from 1997 to 2000. In 2000, he was invited to serve as Clinical Instructor in Medicine and Chief Medical Resident at the University of Alabama at Birmingham.^[1] While at UAB, Voros was inspired to pursue cardiology and non-invasive cardiovascular imaging.Under the mentorship of Navin Nanda and Gerald Pohost, both globally renowned expert cardiologists and scientists in their respective specialties, Voros furthered his interest in cardiovascular imaging. As he would later discover, this interest would become his passion. Voros was one of the first handful of physicians globally, who were Level III trained in cardiovascular magnetic resonance imaging and computed tomography.

In 2008, Fox 7 News aired a Health Edge special on The Family Heart Disease Program, a Voros-led initiative that identified family members at high risk of developing coronary artery disease and educated them on how to reduce the risks for themselves and their families.^[2][3]

Most recently, Voros was interviewed on Fox 5 News for a Health Watch special on the Corus CAD test,a blood-based test that measures the expression levels of 23 genes that have demonstrated to indicate obstructive coronary artery disease (CAD).^[4]

Voros has published extensively in the field of advanced cardiovascular imaging. He regularly lectures at national and international meetings, including many prestigious conferences sponsored by the American College of Cardiology.^[5] Working with CardioDx, Inc (Palo Alto, CA), he recently published a paper in the Annals of Internal Medicine describing the first genomic blood-based diagnostic test for the detection of significant blockages in the heart.^[6] Voros is independently funded to do important clinical research on advanced cardiovascular imaging, atherosclerosis and lipoprotein abnormalities. Voros and his team recently completed the ATLANTA I and ATLANTA II studies, which focused on assessing the morphology and other characteristics of blockages in the heart using heart catheterization, cardiac CT, intravascular ultrasound, and near infrared spectroscopy.

In 2010, Voros and his team published an article on their advanced method of coronary artery calcium quantification, the lesion-specific calcium score. This method has been shown, through research, to be superior to the Agatston score.

Publications

• Garan H, Voros S: Cardiac Arrhythmias. Chapter 65. Imaging in Cardiovascular Disease. Editors: G. Pohost, R. O'Rourke, P. Shah, D. Berman.
• Voros S. Electrophysiologic Disorders. Editors: G. Pohost, K. Nayak. Informa Healthcare 2006.
• Voros, S; Nanda, NC; Thakur, AC; Narayan, VK; Samal, AK. "Lambl's Excrescences Involving the Pulmonary Valve Detected by Transesophageal Echocardiography". Echocardiography. 1999 (16): 35–39. 
• Thakur, AC; Voros, S; Nanda, NC; Gomez, CR; Terry, JB; Tulyapronchote, R. "Ocako: Transesophageal Echocardiographic Diagnosis of Proximal Coronary Artery Stenosis in Patients with Ischemic Stroke". Echocardiography. 1999 (16): 159–165. 
• Nanda, NC; Thakur, AC; Thakur, D; Narayan, VK; Espinal, MA; Shoeb, G; Samal, AK; Voros, S; Aaluri, SR; Ocak, O; John, AS; Pasia, AT; Aikens, M. "Transesophageal echocardiographic examination of left subclavian artery branches". Echocardiography. 1999 (16): 271–277. 
• Voros, S; Nanda, NC; Thakur, AC; Winokur, TS; Samal, AK. "Lambl's excrescences (Valvular Strands)". Echocardiography. 1999 (16): 399–413. 
• Samal, AK; Nanda, NC; Thakur, AC; Narayan, VK; Ocak, O; Lee, TY; Voros, S; Jindal, A; Winokur, TS. "Three-Dimensional Echocardiographic Assessment of Lambl's Excrescences on the Aortic Valve". Echocardiography. 1999 (16): 437–441. 
• Voros, S; Nanda, NC (2000). "Transesophageal Echocardiographic Assessment of Proximal Coronary Artery Stenosis in Elderly Patients with Ischemic Stroke". Am J Geriatric Cardiology. 9 (4): 197–203. doi:10.1111/j.1076-7460.2000.80038.x. 
• Biederman, RWW; Sorrell, VL; Nanda, NC; Voros, S; Thakur, AC (2001). "Transesophageal Echocardiographic Assessment of Coronary Stenosis: A Decade of Experience". Echocardiography. 18 (1): 49–57. doi:10.1046/j.1540-8175.2001.00049.x. 
• Voros, S; Nanda, NC; Samal, AK; Gomez, CR; Puri, VK; Jindal, A; Terry, JB; Tulyapronchote, R; Thakur, AC (2001). "Transesophageal Echocardiography Performed in Stroke Patients to Exclude Cardiac Sources of Embolism Accurately Detects Significant Proximal Coronary Artery Stenosis and Often Changes Management". American Heart Journal. 142: 916–922. doi:10.1067/mhj.2001.118745. 
• Voros, S; Kramer, CM (2003). "Clinical applications of cardiovascular magnetic resonance imaging". Heartwise. 6 (4): 4–10. 
• Keser, N; Nanda, NC; Miller, AP; Voros, S; Soydas, C; Agrawal, G; Liguori, C; Naftel, D; Pacifico, AD; Kirklin, JK; McGiffin, DC; Holman, WL (May 2003). "Hemodynamic Evaluation of Normally Functioning Sulzer Carbomedics Prosthetic Valves". Ultrasound Med Biol. 29 (5): 649–57. doi:10.1016/s0301-5629(02)00777-9. 
• Patel, RAG; Dimarco, JP; Akar, JG; Voros, S; Kramer, CM (2005). "Chagas myocarditis and syncope". J Cardiovasc Magn Reson. 7: 685–688. 
• Voros S, Kramer CM. "Cardiovascular MRI: State of the Art" in Clinical Cardiology Reviews, (Bentham Science Publishers, London) 2005;1:181-188.
• Szilard Voros MD, Zequan Yang MD, PhD, Christina M. Bove MD, Wesley D. Gilson PhD, Frederick H. Epstein PhD, Brent A. French, PhD, Stuart S. Berr PhD, Sanford P. Bishop PhD, DVM, Hiroaki Matsubara MD, PhD, Robert M. Carey MD, Christopher M. Kramer MD, FACC. The AT2 Receptor Mediates Most of the Benefit of AT1 Receptor Blockade During Post-Infarction Left Ventricular Remodeling" Am J Physiol Heart Circ Physiol 2006 Mar;290(3):H1004-10.
• Bove, CM; DiMaria, JM; Voros, S; Conaway, MR; Kramer, CM (2006). "Dobutamine Response and Myocardial Infarct Transmurality: Functional Improvement after Coronary ArteryBypass Grafting—Initial Experience". Radiology. 240 (3): 835–842. doi:10.1148/radiol.2403051150. 
• Akram, K; Silverman, ME; Voros, S (2006). "A Unique Case of Pulmonary Artery Leiomyosarcoma". J Natl Med Assoc. 98 (12): 1995–96. 
• Isbell DC, Voros S, Yang Z, DiMaria JM, Berr SS, French BA, Epstein FH, Bishop SP, Wang H, Roy RJ, Kemp BA, Matsubara H, Carey RM, Kramer CM. "Interaction Between Bradykinin Subtype 2 and Angiotensin II Type 2 Receptors During Post-MI Left Ventricular Remodeling" Am J Physiol Heart Circ Physiol 2007 Dec;293(6):H3372-8.
• Schietinger, BJ; Voros, S; Isbell, DC; Meyer, CH; Christopher, JM; Kramer, CM (Oct 2007). "Can late gadolinium enhancement by cardiovascular magnetic resonance identify coronary artery disease as the etiology of new onset congestive heart failure?". Int J Cardiovasc Imaging. 23 (5): 595–602. doi:10.1007/s10554-006-9200-x. 
• Akram, Kamran; Voros, Szilard (Oct 2008). "Absolute Coronary Artery Calcium Scores are superior to MESA percentile rank in predicting obstructive coronary artery disease". Int J Cardiovasc Imaging. 24 (7): 743–9. doi:10.1007/s10554-008-9305-5. 
• Voros, Szilard (2008). "Can Computed Tomography Angiography of the Coronary Arteries Characterize Atherosclerotic Plaque Composition? Is the CAT (Scan) Out of the Bag?". J. Am. Coll. Cardiol. Intv. 1: 183–185. doi:10.1016/j.jcin.2008.02.002. 
• Akram, Kamran; O'Donnell, Robert E.; King, Spencer; Superko, H. Robert; Agatston, Arthur; Voros, Szilard (2009). "Influence of Symptomatic Status on the Prevalence of Obstructive Coronary Artery Disease in Patients with Zero Calcium Score". Atherosclerosis. 203: 533–537. doi:10.1016/j.atherosclerosis.2008.07.008. 
• Akram K, Voros S. "Influence of symptoms and age on the predictive value of coronary artery calcium scanning. J Am Coll Cardiol. 2008 Dec 16;52(25):2214.
• Akram K, Rinehart S, Voros S. Coronary arterial atherosclerotic plaque imaging by contrast-enhanced computed tomography: fantasy or reality? J Nucl Cardiol. 2008 Nov-Dec;15(6):818-29.
• Voros S. "What are the potential advantages and disadvantages of volumetric CT scanning? J Cardiovasc Comput Tomogr. 2009 Mar-Apr;3(2):67-70.
• Rinehart, S; Vazquez, G; Qian, Z; Voros, S (2009). "Coronary Plaque Imaging with Multi-Slice Computed Tomographic Angiography and Intravascular Ultrasound: A Close Look Inside and Out". J Inv Cardiol. 21 (7): 367–372. 
• Qian Z, Marvasty I, Anderson H, Rinehart S, Voros S. "Lesion-specific coronary artery calcium quantification better predicts cardiac events". Proc. of IEEE International Symposium on Biomedical Imaging (ISBI), p237-240, 2009.
• Akram, K; Anderson, HD; Voros, S (Nov 2009). "Quantification of left ventricular parameters obtained by automated software for 64-slice multidetector computed tomography and comparison with magnetic resonance imaging". Cardiovasc Intervent Radiol. 32 (6): 1154–60. doi:10.1007/s00270-009-9706-4. 
• Voros, S (May 2009). "Does imaging paint a sugar-coated picture of diabetic vessels?" : plaque composition in diabetics by IVUS and CT angiography". J Nucl Cardiol. 16 (3): 339–44. doi:10.1007/s12350-009-9069-x. 
• Voros, S; Joshi, PH; Vazquez, G; Roth, G; Murrieta, L; Rinehart, S; Qian, Z; Miller, J (2010). "Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: Rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study". J Cardiovasc Comput Tomogr. 4: 164–172. doi:10.1016/j.jcct.2010.03.005. 
• George Barbier, Jesus Gustavo Vazquez Figueroa, Sarah Rinehart, Zhen Qian, Parag Joshi, Charles Wilmer, Szilard Voros. "Tissue Characterization of a Papillary Fibroelastoma on the Aortic Valve by Contrast-Enhanced 320-Detector Row Computed Tomography Accepted Manuscript, 7 June 2010. Journal of Cardiovascular Computed Tomography DOI: 10.1016/j.jcct.2010.05.020
• Zhen Qian, Hunt Anderson, Idean Marvasty, Kamran Akram, Gustavo Vazquez, Sarah Rinehart, Szilard Voros. Lesion- and Vessel-Specific Coronary Artery Calcium Scores are Superior to Whole-Heart Agatston and Volume Scores in the Diagnosis of Obstructive Coronary Artery Disease. Journal of Cardiovascular Computed Tomography. DOI: 10.1016/j.jcct.2010.09.001.
• Sara Mobasseri, Szilard Voros. Clinical Trial Report: The Use of Coronary CT Angiography to Evaluate Chest Pain Patients—The ROMICAT (Rule Out Myocardial Infarction using Computer-Assisted Tomography) Study. Current Cardiovascular Imaging Reports. DOI: 10.1007/s12410-010-9051-7.
• Rinehart S, Vazquez G, Qian Z, Murrieta L, Christian K, Voros S. "Quantitative Measurements of Coronary Arterial Stenosis, Plaque Geometry and Composition are Highly Reproducible with a Standardized Coronary Arterial Computed Tomographic Approach in High-Quality CT Datasets. J Cardiovasc Comput Tomogr. 2011 Jan-Feb;5(1):35-43.
• Liu, Q; Qian, Z; Marvasty, I; Rinehart, S; Voros, S; Metaxas, DN (2010). "Lesion-specific coronary artery calcium quantification for predicting cardiac event with multiple instance support vector machines". Med Image Comput Comput Assist Interv. 13 (1): 484–92. doi:10.1007/978-3-642-15705-9_59. 
• Joshi, PH; Krivitsky, E; Qian, Z; Vazquez, G; Voros, S; Miller, J (Aug 2010). "Do We Know When and How to Lower Lipoprotein(a)?". Curr Treat Options Cardiovasc Med. 12 (4): 396–407. doi:10.1007/s11936-010-0077-6. 
• Rosenberg, Steven; Elashoff, Michael R.; Beineke, Philip; Daniels, Susan E.; Wingrove, James A.; Tingley, Whittemore G.; Sager, Philip T.; Sehnert, Amy J.; Yau, May; Kraus, William E.; Newby, L. Kristin; Schwartz, Robert S.; Voros, Szilard; Ellis, Stephen G.; Tahirkheli, Naeem; Waksman, Ron; McPherson, John; Lansky, Alexandra; Winn, Mary E.; Schork, Nicholas J.; Topol, Eric J. (2010). "Multicenter Validation of the Diagnostic Accuracy of a Blood-Based Gene Expression Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients". Ann Intern Med. 153: 425–434. doi:10.7326/0003-4819-153-7-201010050-00005. 
• "ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults". J Am Coll Cardiol. 56: e50–e103. 2010. doi:10.1016/j.jacc.2010.09.001. PMID 21144964. 
• Voros, Szilard; Rinehart, Sarah; Qian, Zhen; Vazquez, Gustavo; Anderson, Hunt; Murrieta, Laura; Wilmer, Charles; Carlson, Harold; Taylor, Kenneth; Ballard, William; Karmpaliotis, Dimitri; Kalynych, Anna; Brown III, Charles (Feb 2011). "Prospective Validation of Standardized, 3-Dimensional, Quantitative Coronary Computed Tomographic Plaque Measurements using Radiofrequency Backscatter Intravascular Ultrasound as Reference Standard in Intermediate Coronary Arterial Lesions: Results from the ATLANTA I Study". JACC Cardiovasc Interv. 4 (2): 198–208. doi:10.1016/j.jcin.2010.10.008. 
• Szilard Voros, MD, Juan J. Rivera, MD, Daniel S. Berman, MD, Ron Blankstein, MD, Matthew J. Budoff, MD, Ricardo C. Cury, MD, Milind Y. Desai, MD, Damini Dey, PhD, Sandra S. Halliburton, PhD, Harvey S. Hecht, MD, Khurram Nasir, MD, MPH, Raul D. Santos, MD, Michael D. Shapiro, DO, Allen J. Taylor, MD, FACC, FAHA, Uma S. Valeti, MD, Phillip M. Young, MD, Gaby Weissman, MD. Guideline for minimizing radiation exposure during acquisition of coronary artery calcium scans with the use of multidetector computed tomography: A report by the Society for Atherosclerosis Imaging-Prevention Tomographic Imaging and Prevention Councils in collaboration with the Society of Cardiovascular Computed Tomography. Journal of Cardiovascular Computed Tomography. In Press. doi:10.1016/j.jcct.2011.01.003
• Sharma, A; Kasim, M; Joshi, PH; Qian, Z; Krivitsky, E; Akram, K; Rinehart, S; Vazquez, G; Miller, J; Rohman, MS; Voros, S (2011). "Abnormal Lipoprotein(a) Levels Predict Coronary Artery Calcification in Southeast Asians but not in Caucasians: use of noninvasive imaging for evaluation of an emerging risk factor. Journal of Cardiovascular Translational Research". J Cardiovasc Transl Res. 4: 470–476. doi:10.1007/s12265-011-9273-3. 
• Elashoff, Michael R; Wingrove, James A; Beineke, Philip; Daniels, Susan E; Tingley, Whittemore G; Rosenberg, Steven; Voros, Szilard; Kraus, William E; Ginsburg, Geoffrey S; Schwartz, Robert S; Ellis, Stephen G; Tahirkheli, Naheem; Waksman, Ron; McPherson, John; Lansky, Alexandra J; Topol, Eric J (2011). "Development of a Blood-based Gene Expression Algorithm for Assessment of Obstructive Coronary Artery Disease in Non-Diabetic Patients". BMC Medical Genomics. 4: 26. doi:10.1186/1755-8794-4-26. 
• Voros, S; Rinehart, S; Qian, Z; Joshi, P; Vazquez, G; Fischer, C; Belur, P; Hulten, E; Villines, TC (May 2011). "Coronary Atherosclerosis Imaging by Coronary CT Angiography Current Status, Correlation With Intravascular Interrogation and Meta-Analysis". JACC Cardiovasc Imaging. 4 (5): 537–48. 
• Qian, Z; Joshi, PH; Shaukat, AF; Laury, T; Kirkland, B; Meyers, L; Drew, A; Angel, E; Krivitsky, E; Bajpai, A; Vazquez, G; O'Rourke, C; Carr, JJ; Rinehart, S; Voros, S (2011). "Relationship between chest lateral width, tube current, image noise, and radiation exposure associated with coronary artery calcium scanning on 320-detector row CT.". J Cardiovasc Comput Tomogr. 5 (4): 231–239. doi:10.1016/j.jcct.2011.06.006. 
• R. Hachamovitch, B. Nutter, M.A. Hlatky, L.J. Shaw, M.L. Ridner, S. Dorbala, R.S.B. Beanlands, B.J.W. Chow, E. Branscomb, P. Chareonthaitawee, W.G. Weigold, S.Voros, S. Abbara, T. Yasuda, J.E. Jacobs, J. Lesser, D.S. Berman, L. Thomson, S. Raman, G.V. Heller, A. Schussheim, R. Brunken, K.A. Williams, S. Farkas, D. Delbeke, U. J. Schoepf, N. Reichek, S. Rabinowitz, S.R. Sigman, R. Patterson, C.R. Corn, R. White, Ella Kazerooni, J. Corbett, S. Bokhari, J. Machac, M. Guarneri, S. Borges-Neto, J.W. Millstine, J. Caldwell, Arrighi, U. Hoffmann, M. Budoff, J.Lima,35 J.R. Johnson,2 B. Johnson,2 M. Gaber,2 J. A. Williams,2 C. Foster, J. Hainer, M.F.Di Carli, for the SPARC study Investigators. Patient Management after Non-invasive Cardiac Imaging: Results From the Study of Myocardial Perfusion and Coronary Anatomy Imaging Roles in Coronary Artery Disease (SPARC). J Am Coll Cardiol. In Press.
• Rinehart, S; Qian, Z; Vazquez, G; Joshi, P; Kirkland, B; Bhatt, K; Marvasty, I; Christian, K; Voros, S. "Demonstration of the Glagov phenomenon in vivo by CT coronary angiography in subjects with elevated Framingham risk". Int J Cardiovasc Imaging. 28: 1589–1599. doi:10.1007/s10554-011-9979-y. 
• Kulp, S; Gao, M; Zhang, S; Qian, Z; Voros, S; Metaxas, D; Axel, L (2011). "Using high resolution cardiac CT data to model and visualize patient-specific interactions between trabeculae and blood flow". Med Image Comput Comput Assist Interv. 14 (1): 468–75. doi:10.1007/978-3-642-23623-5_59. 
• Qian, Z; Marvasty, I; Rinehart, S; Voros, S (Sep 2011). "A lesion-specific coronary artery calcium quantification framework for the prediction of cardiac events". IEEE Trans Inf Technol Biomed. 15 (5): 673–80. doi:10.1109/titb.2011.2162074. 
• Voros, S; Qian, Z (2012). "Agatston score tried and true: By contrast, can we quantify calcium on CTA?". Journal of Cardiovascular Computed Tomography. 6: 45–47. doi:10.1016/j.jcct.2011.12.002. 

References