Synthesizing Unit

Synthesizing Units (SUs) are generalized enzymes that follow the rules of classic enzyme kinetics with two modifications:

product formation is not taken to be a function of substrate concentrations but of substrate fluxes that arrive at the SUs
the dissociation rate of the substrate-SU complex to (unchanged) substrate and (unbounded) SU is assumed to be small.

Modifications of classic theory

Extension

The first modification is an extension of the classic theory; if arrival fluxes are taken proportional to substrate concentrations, the classic theory results. This extension allows application in spatially heterogeneous environments (such as in living cells), and to treat photons and molecules in the same framework (important in photosynthesis).

Simplification

The second modification allows a substantial simplification of the classic theory, and so application in complex metabolic networks.

Theory on Synthesizing Units is used in Dynamic Energy Budget theory, where 4 basic modes are distinguished:

the substrates can be substitutable or supplementary (= complementary); if the transformations A -> C and B -> C can occur, substrates A and B are said to be substitutable with respect to their transformation to C, if both are required to produce C they are said to be supplementary
the processing of these substrates by SUs can be sequential or parallel; if in the transformation A + B -> C the binding of substrate A to the SU does not affect that of B, these substrates are processed simultaneously, if not these substrates are processed sequentially

Mixtures of the 4 basic modes can occur, especially if the substrates represent generalized compounds, rather than pure chemical compounds. A generalized compound is a mixture of chemical compounds that does not change in composition.

References

Kooijman SA (July 1998). "The Synthesizing Unit as model for the stoichiometric fusion and branching of metabolic fluxes". Biophys. Chem. 73 (1-2): 179–88. doi:10.1016/S0301-4622(98)00162-8. PMID 17029722.
Kooijman, S.A.L.M; Segel, L.A. (2005). "How growth affects the fate of cellular metabolites" (PDF). Bulletin of mathematical biology. 67 (1): 57–77. doi:10.1016/j.bulm.2004.06.003. PMID 15691539. Retrieved 2009-05-12.

This article is issued from Wikipedia - version of the 5/19/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.