List of highways numbered 81

Route 81 or Highway 81 may refer to:

International

• Asian Highway 81
• European route E81

Canada

• Newfoundland and Labrador Route 81

Korea, South

• National Route 81

Mexico

• Mexican Federal Highway 81

United States

• Interstate 81
  • Interstate 81E (former)
  • Interstate 81S (former)
• U.S. Route 81
• Alabama State Route 81
• Arizona State Route 81 (former)
• Arkansas Highway 81
• California State Route 81
• Connecticut Route 81
• Florida State Road 81
• Georgia State Route 81
• Idaho State Highway 81
• Illinois Route 81
• Iowa Highway 81
• Kentucky Route 81
• Louisiana Highway 81
• Maryland Route 81 (former)
• Massachusetts Route 81
• M-81 (Michigan highway)
• One of two former Minnesota State Highway 81s:
  • Trunk Highway 81 (Minnesota)
  • Minnesota State Highway 81 (pre-1988)
• Missouri Route 81
• Montana Highway 81
• Nebraska Highway 81 (former)
• Nevada State Route 81 (former)
• New Jersey Route 81
• New Mexico State Road 81
• New York State Route 81
• North Carolina Highway 81
• Ohio State Route 81
• Pennsylvania Route 81 (former)
• Rhode Island Route 81
• South Carolina Highway 81
• South Dakota Highway 81 (former)
• Tennessee State Route 81
• Texas State Highway 81
  • Farm to Market Road 81 (Texas)
• Utah State Route 81
• Virginia State Route 81 (former)
• Wisconsin Highway 81

Territories:

• U.S. Virgin Islands Highway 81

Other:

• Route 81 may also refer to Route 81 (Hells Angels)