Serglycin

SRGN

Identifiers

SRGN, PPG, PRG, PRG1, serglycin

External IDs

HomoloGene: 2043 GeneCards: SRGN

Gene ontology
Molecular function	• collagen binding • protein binding
Cellular component	• Golgi apparatus • zymogen granule • mast cell granule • Golgi membrane • extracellular fluid • extracellular region • platelet alpha granule lumen
Biological process	• negative regulation of bone mineralization • maintenance of granzyme B location in T cell secretory granule • T cell secretory granule organization • mast cell secretory granule organization • biomineral tissue development • protein processing • platelet degranulation • protease localization to mast cell secretory granule • negative regulation of cytokine secretion • maintenance of protease location in mast cell secretory granule • granzyme-mediated apoptotic signaling pathway • apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5552


n/a

Ensembl


ENSG00000122862


n/a

UniProt


P10124


n/a

RefSeq (mRNA)


NM_002727 NM_001321053 NM_001321054


n/a

RefSeq (protein)


NP_002718.2 NP_001307982.1 NP_001307983.1


n/a

Location (UCSC)

Chr 10: 69.09 – 69.1 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Serglycin, also known as hematopoetic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.^[2] It is primarily expressed in hematopoietic cells and endothelial cells.^[3]

Function

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.^[2]

References

↑ "Human PubMed Reference:".
1 2 "Entrez Gene: SRGN serglycin".
↑ Kolset, SO; Tveit, H (April 2008). "Serglycin--structure and biology.". Cellular and molecular life sciences : CMLS. 65 (7-8): 1073–85. doi:10.1007/s00018-007-7455-6. PMID 18066495.

Schick BP (2000). "Regulation of expression of megakaryocyte and platelet proteoglycans.". Stem Cells. 14 Suppl 1: 220–31. doi:10.1002/stem.5530140729. PMID 11012225.
Humphries DE; Nicodemus CF; Schiller V; Stevens RL (1992). "The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells.". J. Biol. Chem. 267 (19): 13558–63. PMID 1377686.
Nicodemus CF, Avraham S, Austen KF, et al. (1990). "Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product.". J. Biol. Chem. 265 (10): 5889–96. PMID 2180935.
Mattei MG, Périn JP, Alliel PM, et al. (1989). "Localization of human platelet proteoglycan gene to chromosome 10, band q22.1, by in situ hybridization.". Hum. Genet. 82 (1): 87–8. doi:10.1007/BF00288281. PMID 2714783.
Avraham S, Stevens RL, Nicodemus CF, et al. (1989). "Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA.". Proc. Natl. Acad. Sci. U.S.A. 86 (10): 3763–7. doi:10.1073/pnas.86.10.3763. PMC 287220. PMID 2726751.
Stellrecht CM; Saunders GF (1989). "Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.". Nucleic Acids Res. 17 (18): 7523. doi:10.1093/nar/17.18.7523. PMC 334837. PMID 2798108.
Stevens RL, Avraham S, Gartner MC, et al. (1988). "Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells.". J. Biol. Chem. 263 (15): 7287–91. PMID 2835370.
Périn JP; Bonnet F; Maillet P; Jollès P (1989). "Characterization and N-terminal sequence of human platelet proteoglycan.". Biochem. J. 255 (3): 1007–13. PMC 1135341. PMID 3214420.
Avraham S, Stevens RL, Gartner MC, et al. (1988). "Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue.". J. Biol. Chem. 263 (15): 7292–6. PMID 3366780.
Alliel PM, Périn JP, Maillet P, et al. (1988). "Complete amino acid sequence of a human platelet proteoglycan.". FEBS Lett. 236 (1): 123–6. doi:10.1016/0014-5793(88)80298-9. PMID 3402609.
Hatton MN; Loomis RE; Levine MJ; Tabak LA (1985). "Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex.". Biochem. J. 230 (3): 817–20. PMC 1152688. PMID 4062880.
Schick BP; Jacoby JA (1995). "Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes.". J. Cell. Physiol. 165 (1): 96–106. doi:10.1002/jcp.1041650113. PMID 7559813.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Kolset SO, Mann DM, Uhlin-Hansen L, et al. (1996). "Serglycin-binding proteins in activated macrophages and platelets.". J. Leukoc. Biol. 59 (4): 545–54. PMID 8613703.
Toyama-Sorimachi N, Kitamura F, Habuchi H, et al. (1997). "Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells.". J. Biol. Chem. 272 (42): 26714–9. doi:10.1074/jbc.272.42.26714. PMID 9334256.
Galvin JP, Spaeny-Dekking LH, Wang B, et al. (1999). "Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.". J. Immunol. 162 (9): 5345–50. PMID 10228010.
Schick BP; Gradowski JF; San Antonio JD (2001). "Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells.". Blood. 97 (2): 449–58. doi:10.1182/blood.V97.2.449. PMID 11154222.
Omtvedt LA, Kolset SO, Thoen J, et al. (2001). "Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases.". Scand. J. Rheumatol. 30 (3): 164–6. doi:10.1080/030097401300162941. PMID 11469527.
Metkar SS, Wang B, Aguilar-Santelises M, et al. (2002). "Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.". Immunity. 16 (3): 417–28. doi:10.1016/S1074-7613(02)00286-8. PMID 11911826.

This article is issued from Wikipedia - version of the 7/30/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

Serglycin

Function

References

Further reading