SOCS4

SOCS4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases SOCS4, SOCS7, suppressor of cytokine signaling 4
External IDs MGI: 1914546 HomoloGene: 15442 GeneCards: SOCS4
Orthologs
Species Human Mouse
Entrez

122809

67296

Ensembl

ENSG00000180008

ENSMUSG00000048379

UniProt

Q8WXH5

Q91ZA6

RefSeq (mRNA)

NM_080867
NM_199421

NM_080843

RefSeq (protein)

NP_543143.1
NP_955453.1

NP_543119.2

Location (UCSC) Chr 14: 55.03 – 55.05 Mb Chr 14: 47.28 – 47.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene. [3]

Function

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the 4/12/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.