SH3GLB1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1X43

Identifiers

Aliases

SH3GLB1, Bif-1, PPP1R70, dJ612B15.2, CGI-61, SH3 domain containing GRB2 like endophilin B1

External IDs

MGI: 1859730 HomoloGene: 9337 GeneCards: SH3GLB1

Gene ontology
Molecular function	• protein homodimerization activity • protein binding • identical protein binding • lipid binding • cadherin binding involved in cell-cell adhesion
Cellular component	• cytoplasm • Golgi apparatus • membrane • Golgi membrane • mitochondrial outer membrane • autophagosome membrane • midbody • mitochondrion • extracellular exosome • cytoplasmic vesicle • cell-cell adherens junction
Biological process	• cellular response to glucose starvation • regulation of cytokinesis • regulation of protein stability • positive regulation of autophagosome assembly • positive regulation of autophagy • positive regulation of protein targeting to mitochondrion • cellular response to amino acid starvation • receptor catabolic process • autophagy • protein oligomerization • membrane fission • positive regulation of protein oligomerization • positive regulation of membrane tubulation • autophagic cell death • regulation of macroautophagy • protein localization to vacuolar membrane • apoptotic process • cell-cell adhesion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


51100


54673

Ensembl


ENSG00000097033


ENSMUSG00000037062

UniProt


Q9Y371


Q9JK48

RefSeq (mRNA)


NM_001206651 NM_001206652 NM_001206653 NM_016009


NM_001282037 NM_001282042 NM_019464

RefSeq (protein)


NP_001193580.1 NP_001193581.1 NP_001193582.1 NP_057093.1


NP_001268966.1 NP_062337.1 NP_001268971.1

Location (UCSC)

Chr 1: 86.7 – 86.75 Mb

Chr 3: 144.68 – 144.72 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene.^[3]^[4]^[5]

Interactions

SH3GLB1 has been shown to interact with SH3GLB2^[3] and Bcl-2-associated X protein.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.
1 2 Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, Singh S, Wang HG (June 2001). "Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax". J Biol Chem. 276 (23): 20559–65. doi:10.1074/jbc.M101527200. PMID 11259440.
↑ "Entrez Gene: SH3GLB1 SH3-domain GRB2-like endophilin B1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M (2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. 278 (6): 4160–7. doi:10.1074/jbc.M208568200. PMID 12456676.
Lee SY, Wenk MR, Kim Y, Nairn AC, De Camilli P (2004). "Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 546–51. doi:10.1073/pnas.0307813100. PMC 327184. PMID 14704270.
Karbowski M, Jeong SY, Youle RJ (2004). "Endophilin B1 is required for the maintenance of mitochondrial morphology". J. Cell Biol. 166 (7): 1027–39. doi:10.1083/jcb.200407046. PMC 2172012. PMID 15452144.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG (2005). "Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis". Mol. Cell. Biol. 25 (21): 9369–82. doi:10.1128/MCB.25.21.9369-9382.2005. PMC 1265816. PMID 16227588.
Masuda M, Takeda S, Sone M, Ohki T, Mori H, Kamioka Y, Mochizuki N (2006). "Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms". EMBO J. 25 (12): 2889–97. doi:10.1038/sj.emboj.7601176. PMC 1500852. PMID 16763557.
Lee JW, Jeong EG, Soung YH, Nam SW, Lee JY, Yoo NJ, Lee SH (2006). "Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas". Pathology. 38 (4): 312–5. doi:10.1080/00313020600820880. PMID 16916719.

PDB gallery

1x43: Solution structure of the SH3 domain of Endophilin B1 (Sh3g1b1)

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SH3GLB1

Interactions

References

Further reading