SFRS6

SRSF6
Identifiers
Aliases	SRSF6, B52, HEL-S-91, SFRS6, SRP55, serine/arginine-rich splicing factor 6, serine and arginine rich splicing factor 6
External IDs	MGI: 1915246 HomoloGene: 110783 GeneCards: SRSF6
Gene ontology Molecular function • nucleotide binding • protein binding • RNA binding • nucleic acid binding • pre-mRNA binding • poly(A) RNA binding Cellular component • nuclear speck • nucleoplasm • nucleus Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • negative regulation of keratinocyte differentiation • positive regulation of epithelial cell proliferation involved in lung morphogenesis • mRNA processing • negative regulation of cell death • regulation of alternative mRNA splicing, via spliceosome • mRNA export from nucleus • negative regulation of mRNA splicing, via spliceosome • regulation of wound healing • mRNA splice site selection • regulation of keratinocyte proliferation • alternative mRNA splicing, via spliceosome • mRNA 3'-end processing • negative regulation of gene expression • RNA splicing • response to insulin • RNA export from nucleus • negative regulation of type B pancreatic cell apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6431	67996
Ensembl	ENSG00000124193	ENSMUSG00000016921
UniProt	Q13247	Q3TWW8
RefSeq (mRNA)	NM_006275	NM_026499
RefSeq (protein)	NP_006266.2	NP_080775.3
Location (UCSC)	Chr 20: 43.46 – 43.46 Mb	Chr 2: 162.93 – 162.94 Mb
PubMed search	[1]	[2]
Wikidata

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.^[3][4]

The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.^[4]

References

Further reading