SEC23B

SEC23B
Identifiers
Aliases	SEC23B, CDA-II, CDAII, CDAN2, HEMPAS, CWS7, Sec23 homolog B, coat complex II component
External IDs	MGI: 1350925 HomoloGene: 74571 GeneCards: SEC23B
Gene ontology Molecular function • zinc ion binding • protein binding Cellular component • perinuclear region of cytoplasm • COPII vesicle coat • Golgi membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum membrane • endomembrane system • intracellular membrane-bounded organelle • endoplasmic reticulum • membrane • Golgi apparatus Biological process • protein transport • ER to Golgi vesicle-mediated transport • intracellular protein transport • transport • vesicle-mediated transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10483	27054
Ensembl	ENSG00000101310	ENSMUSG00000027429
UniProt	Q15437 Q5QPE2	Q9D662
RefSeq (mRNA)	NM_032986 NM_001172745 NM_001172746 NM_006363 NM_032985	NM_001252543 NM_001252544 NM_001252545 NM_001281816 NM_019787
RefSeq (protein)	NP_001166216.1 NP_001166217.1 NP_006354.2 NP_116780.1 NP_116781.1	NP_001239472.1 NP_001239473.1 NP_001239474.1 NP_062761.2
Location (UCSC)	Chr 20: 18.51 – 18.56 Mb	Chr 2: 144.56 – 144.59 Mb
PubMed search	[1]	[2]
Wikidata

Protein transport protein Sec23B is a protein that in humans is encoded by the SEC23B gene.^[3][4][5]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[5] Mutations in SEC23B cause an autosomal recessive disorder called congenital dyserythropoietic anemia type II (CDAII).

References

Further reading