SDCBP

SDCBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N99, 1NTE, 1OBX, 1OBY, 1OBZ, 1R6J, 1V1T, 1W9E, 1W9O, 1W9Q, 1YBO, 4Z33
Identifiers
Aliases	SDCBP, MDA-9, ST1, SYCL, TACIP18, MDA9, syndecan binding protein
External IDs	MGI: 1337026 HomoloGene: 4110 GeneCards: SDCBP
Gene ontology Molecular function • protein homodimerization activity • growth factor binding • protein N-terminus binding • ephrin receptor binding • frizzled binding • glycoprotein binding • interleukin-5 receptor binding • neurexin family protein binding • protein C-terminus binding • protein binding • identical protein binding • protein heterodimerization activity • cytoskeletal adaptor activity • syndecan binding • cell adhesion molecule binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • extracellular vesicle • cytosol • blood microparticle • endoplasmic reticulum membrane • membrane • focal adhesion • melanosome • adherens junction • plasma membrane • interleukin-5 receptor complex • extracellular fluid • extracellular region • cell junction • endoplasmic reticulum • membrane raft • extracellular exosome • cytoskeleton • nucleus • cell-cell adherens junction Biological process • positive regulation of transforming growth factor beta receptor signaling pathway • intracellular signal transduction • positive regulation of extracellular exosome assembly • negative regulation of receptor internalization • protein targeting to membrane • ephrin receptor signaling pathway • substrate-dependent cell migration, cell extension • positive regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of JNK cascade • positive regulation of epithelial to mesenchymal transition • regulation of mitotic cell cycle • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of exosomal secretion • Ras protein signal transduction • positive regulation of phosphorylation • actin cytoskeleton organization • chemical synaptic transmission • cell-cell adhesion • positive regulation of cell growth • positive regulation of cell migration • positive regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6386	53378
Ensembl	ENSG00000137575	ENSMUSG00000028249
UniProt	O00560	O08992
RefSeq (mRNA)	NM_001007067 NM_001007068 NM_001007069 NM_001007070 NM_005625	NM_001098227 NM_016807
RefSeq (protein)	NP_001007068.1 NP_001007069.1 NP_001007070.1 NP_001007071.1 NP_005616.2	NP_001091697.1 NP_058087.2
Location (UCSC)	Chr 8: 58.55 – 58.58 Mb	Chr 4: 6.37 – 6.41 Mb
PubMed search	[1]	[2]
Wikidata

Syntenin-1 is a protein that in humans is encoded by the SDCBP gene.^[3]

Function

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.^[4]

Interactions

SDCBP has been shown to interact with:

• EFNB1,^[5]
• GRIK1,^[6]
• GRIK2,^[6][7]
• Interleukin 5 receptor alpha subunit,^[8]
• Merlin,^[9]
• RAB5A,^[10]
• SOX4,^[8]
• TRAF6,^[11] and
• ULK1.^[10]

References

Further reading

PDB gallery
1n99: CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN  1nte: CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN  1obx: CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH AN INTERLEUKIN 5 RECEPTOR ALPHA PEPTIDE.  1oby: CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH A SYNDECAN-4 PEPTIDE.  1obz: CRYSTAL STRUCTURE OF THE COMPLEX OF THE PDZ TANDEM OF SYNTENIN WITH AN INTERLEUKIN 5 RECEPTOR ALPHA PEPTIDE.  1r6j: Ultrahigh resolution Crystal Structure of syntenin PDZ2  1v1t: CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEYKV PEPTIDE  1w9e: CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEFYF PEPTIDE  1w9o: CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEYYV PEPTIDE  1w9q: CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEFAF PEPTIDE  1ybo: Crystal structure of the PDZ tandem of human syntenin with syndecan peptide