S100A8

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV

Identifiers

Aliases

S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8

External IDs

MGI: 88244 HomoloGene: 2225 GeneCards: S100A8

Gene ontology
Molecular function	• Toll-like receptor 4 binding • RAGE receptor binding • microtubule binding • protein binding • calcium ion binding • arachidonic acid binding • zinc ion binding • metal ion binding
Cellular component	• nucleus • cytoskeleton • cytosol • extracellular exosome • membrane • plasma membrane • cytoplasm • extracellular region • extracellular fluid
Biological process	• regulation of inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • immune system process • positive regulation of inflammatory response • neutrophil chemotaxis • positive regulation of intrinsic apoptotic signaling pathway • defense response to fungus • response to ethanol • chemokine production • response to zinc ion • acute inflammatory response • defense response to bacterium • leukocyte migration involved in inflammatory response • peptidyl-cysteine S-nitrosylation • sequestering of zinc ion • neutrophil aggregation • response to lipopolysaccharide • chemotaxis • positive regulation of peptide secretion • chronic inflammatory response • astrocyte development • wound healing • apoptotic process • positive regulation of cell growth • autophagy • inflammatory response • regulation of cytoskeleton organization • cytokine production • positive regulation of NF-kappaB transcription factor activity • innate immune response
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6279


20201

Ensembl


ENSG00000143546


ENSMUSG00000056054

UniProt


P05109


P27005

RefSeq (mRNA)


NM_002964 NM_001319196 NM_001319197 NM_001319198 NM_001319201


NM_013650

RefSeq (protein)


NP_002955.2 NP_001306126.1 NP_001306127.1 NP_001306130.1


NP_038678.1

Location (UCSC)

Chr 1: 153.39 – 153.39 Mb

Chr 3: 90.67 – 90.67 Mb

PubMed search

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^[2]

Wikidata

View/Edit Human

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S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.^[3] It is also known as calgranulin A.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.^[3]

References

Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology.". Trends Biochem. Sci. 21 (4): 134–40. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470.
Kerkhoff C, Klempt M, Sorg C (1999). "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9).". Biochim. Biophys. Acta. 1448 (2): 200–11. doi:10.1016/S0167-4889(98)00144-X. PMID 9920411.
Nacken W, Roth J, Sorg C, Kerkhoff C (2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity.". Microsc. Res. Tech. 60 (6): 569–80. doi:10.1002/jemt.10299. PMID 12645005.
Roth J, Vogl T, Sorg C, Sunderkötter C (2004). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules.". Trends Immunol. 24 (4): 155–8. doi:10.1016/S1471-4906(03)00062-0. PMID 12697438.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
Lemarchand P, Vaglio M, Mauël J, Markert M (1992). "Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation.". J. Biol. Chem. 267 (27): 19379–82. PMID 1326551.
Schäfer T, Sachse GE, Gassen HG (1991). "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells.". Biol. Chem. Hoppe-Seyler. 372 (1): 1–4. doi:10.1515/bchm3.1991.372.1.1. PMID 2039599.
Dorin JR, Emslie E, van Heyningen V (1991). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3.". Genomics. 8 (3): 420–6. doi:10.1016/0888-7543(90)90027-R. PMID 2149559.
Wilkinson MM, Busuttil A, Hayward C, et al. (1989). "Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues.". J. Cell. Sci. 91 (2): 221–30. PMID 3267695.
Odink K, Cerletti N, Brüggen J, et al. (1987). "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis.". Nature. 330 (6143): 80–2. doi:10.1038/330080a0. PMID 3313057.
Lagasse E, Clerc RG (1988). "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.". Mol. Cell. Biol. 8 (6): 2402–10. PMC 363438. PMID 3405210.
Dorin JR, Novak M, Hill RE, et al. (1987). "A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene.". Nature. 326 (6113): 614–7. doi:10.1038/326614a0. PMID 3561500.
Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
Umekawa T, Kurita T (1995). "Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone.". Biochem. Mol. Biol. Int. 34 (2): 309–13. PMID 7849642.
Engelkamp D, Schäfer BW, Mattei MG, et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
Roth J, Burwinkel F, van den Bos C, et al. (1993). "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner.". Blood. 82 (6): 1875–83. PMID 8400238.
Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.". J. Dent. Res. 72 (2): 517–23. doi:10.1177/00220345930720020801. PMID 8423249.
Marti T, Erttmann KD, Gallin MY (1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin.". Biochem. Biophys. Res. Commun. 221 (2): 454–8. doi:10.1006/bbrc.1996.0616. PMID 8619876.

PDB gallery

1mr8: MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8 FROM HUMAN

1xk4: Crystal structure of human calprotectin(S100A8/S100A9)

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S100A8

References

Further reading