Ribose-5-phosphate—ammonia ligase
ribose-5-phosphate-ammonia ligase | |||||||||
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Identifiers | |||||||||
EC number | 6.3.4.7 | ||||||||
CAS number | 9082-52-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a ribose-5-phosphate-ammonia ligase (EC 6.3.4.7) is an enzyme that catalyzes the chemical reaction
- ATP + ribose 5-phosphate + NH3 ADP + phosphate + 5-phosphoribosylamine
The 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH3, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is ribose-5-phosphate:ammonia ligase (ADP-forming). Other names in common use include 5-phosphoribosylamine synthetase, ribose 5-phosphate aminotransferase, and ammonia-ribose 5-phosphate aminotransferase. This enzyme participates in purine metabolism.
References
- Reem GH (1968). "Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis". J. Biol. Chem. 243 (21): 5695–701. PMID 5699059.
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