Reptilase time

Reptilase time (RT) is a blood test used to detect deficiency or abnormalities in fibrinogen,^[1]^[2] especially in cases of heparin contamination.

Reptilase, an enzyme found in the venom of Bothrops snakes, has activity similar to thrombin. Unlike thrombin, reptilase is resistant to inhibition by antithrombin III. Thus, the reptilase time is not prolonged in blood samples containing heparin, hirudin, or direct thrombin inhibitors, whereas the thrombin time will be prolonged in these samples. Reptilase also differs from thrombin by releasing fibrinopeptide A, but not fibrinopeptide B, in its cleavage of fibrinogen.

Other causes of prolonged reptilase time include the presence of fibrin degradation products, which interfere with fibrin polymerization.

References

↑ Van Cott EM, Smith EY, Galanakis DK (August 2002). "Elevated fibrinogen in an acute phase reaction prolongs the reptilase time but typically not the thrombin time". Am. J. Clin. Pathol. 118 (2): 263–8. doi:10.1309/WUB3-72JT-E50M-EU8J. PMID 12162688.
↑ Johnson PJ, White Y, Woolf IL, Williams R (October 1977). "Reptilase time in cirrhosis and hepatocellular carcinoma". Br Med J. 2 (6091): 869–70. doi:10.1136/bmj.2.6091.869-a. PMC 1631704. PMID 200301.

Myeloid blood tests (CPT 85002–85999)

Clotting

CBC Platelet count Mean platelet volume vWF: Ristocetin-induced platelet aggregation

clotting factors:	Prothrombin time Partial thromboplastin time Thrombin time Activated clotting time

other/general:	coagulation Bleeding time animal enzyme Reptilase time Ecarin clotting time Dilute Russell's viper venom time Thromboelastography Thrombodynamics test

fibrinolysis:	Euglobulin lysis time D-dimer

Red blood cell indices

CBC	RBC count Hematocrit Hemoglobin

ratios:	Mean corpuscular hemoglobin Mean corpuscular hemoglobin concentration Mean corpuscular volume Red blood cell distribution width

Fetal hemoglobin:	Apt–Downey test Kleihauer–Betke test

Other	Reticulocyte index Haptoglobin Mentzer index

CFU-GM

Other

This article is issued from Wikipedia - version of the 5/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.