Rate of infusion

In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective.

Abbreviations include K_in,^[1] K₀,^[2] or R₀.

It can be calculated as the steady-state concentration in the plasma multiplied by the clearance:

$\textstyle K_{in}=C_{ss}\cdot CL$

References

Concepts in pharmacology

Pharmacokinetics	(L)ADME: (Liberation) Absorption Distribution Metabolism Excretion (Clearance) Loading dose Volume of distribution (Initial) Rate of infusion Compartment Bioequivalence Bioavailability Onset of action Biological half-life Mean residence time Plasma protein binding Therapeutic index (Median lethal dose, Effective dose)

Pharmacodynamics	Mechanism of action Toxicity (Neurotoxicology) Dose–response relationship (Efficacy, Potency) Antimicrobial pharmacodynamics: Minimum inhibitory concentration (Bacteriostatic) Minimum bactericidal concentration (Bactericide)

Agonism and antagonism	Agonist: Inverse agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Antagonist: Competitive antagonist Irreversible antagonist Physiological antagonist Other: Binding Affinity Binding selectivity Functional selectivity

Other	Drug tolerance: Tachyphylaxis Drug resistance: Antibiotic resistance Multiple drug resistance

Drug discovery strategies	Classical pharmacology Reverse pharmacology

Related fields/subfields	Pharmacogenetics Pharmacogenomics Neuropsychopharmacology (Neuropharmacology, Psychopharmacology)

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