40S ribosomal protein S14

RPS14
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS14, EMTB, S14, ribosomal protein S14
External IDs	HomoloGene: 90926 GeneCards: RPS14
Gene ontology Molecular function • small ribosomal subunit rRNA binding • structural constituent of ribosome • translation regulator activity • protein binding • RNA binding • poly(A) RNA binding • mRNA 5'-UTR binding Cellular component • cytoplasm • cytosol • ribosome • membrane • focal adhesion • intracellular ribonucleoprotein complex • cytosolic small ribosomal subunit • nucleolus • mitochondrion • extracellular exosome • extracellular matrix • nucleoplasm Biological process • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • maturation of SSU-rRNA • viral transcription • negative regulation of transcription from RNA polymerase II promoter • SRP-dependent cotranslational protein targeting to membrane • translational initiation • erythrocyte differentiation • ribosomal small subunit assembly • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • rRNA processing • translation • regulation of translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6208	n/a
Ensembl	ENSG00000164587	n/a
UniProt	P62263	n/a
RefSeq (mRNA)	NM_005617 NM_001025070 NM_001025071	n/a
RefSeq (protein)	NP_001020241.1 NP_001020242.1 NP_005608.1	n/a
Location (UCSC)	Chr 5: 150.44 – 150.45 Mb	n/a
PubMed search	[1]	n/a
Wikidata

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.^[2][3][4]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[4]

References

Further reading