RASGRF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2IJE

Identifiers

Aliases

RASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1

External IDs

MGI: 99694 HomoloGene: 74972 GeneCards: RASGRF1

Genetically Related Diseases

refractive error^[1]

Gene ontology
Molecular function	• Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • glutamate receptor binding • Ras guanyl-nucleotide exchange factor activity
Cellular component	• cytosol • growth cone • neuron projection • plasma membrane
Biological process	• intracellular signal transduction • MAPK cascade • regulation of Rho protein signal transduction • positive regulation of GTPase activity • signal transduction • regulation of Rac protein signal transduction • regulation of synaptic plasticity • long-term memory • regulation of Ras protein signal transduction • regulation of neuronal synaptic plasticity • neuron projection development • regulation of N-methyl-D-aspartate selective glutamate receptor activity • activation of GTPase activity • cell proliferation • small GTPase mediated signal transduction • positive regulation of Ras protein signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5923


19417

Ensembl


ENSG00000058335


ENSMUSG00000032356

UniProt


Q13972


P27671

RefSeq (mRNA)


NM_001145648 NM_002891 NM_153815


NM_001039655 NM_011245

RefSeq (protein)


NP_002882.3 NP_722522.1


NP_035375.1

Location (UCSC)

Chr 15: 78.96 – 79.09 Mb

Chr 9: 89.91 – 90.03 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. ^[4]

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].

RASGRF1

References

Further reading