Phenylbiguanide

Phenylbiguanide
Legal status
Legal status
  • UN: Unscheduled
Identifiers
CAS Number 102-02-3
PubChem (CID) 4780
ChemSpider 4616
UNII W8PKA3T2I3
ChEBI CHEBI:75377
ChEMBL CHEMBL13791
Chemical and physical data
Formula C8H11N5
Molar mass 177.206
3D model (Jmol) Interactive image
Melting point 135–142 °C (275–288 °F)

Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.[2]

Derivatives

References

  1. Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats., Journal of Pharmacology and Experimental Therapeutics, 1993, PMID 8450478
  2. Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens., Brain Research., 1991, PMID 1711914


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