Phenprocoumon

Phenprocoumon
Clinical data
Trade names Marcoumar, Marcumar, Falithrom
AHFS/Drugs.com International Drug Names
MedlinePlus a699003
ATC code B01AA04 (WHO)
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Protein binding 99%
Metabolism hepatic to inactive metabolites
Biological half-life 5 to 6 days
Identifiers
CAS Number 435-97-2 YesY
PubChem (CID) 9908
IUPHAR/BPS 6839
DrugBank DB00946 YesY
ChemSpider 10441592 YesY
UNII Q08SIO485D YesY
KEGG D05457 YesY
ChEBI CHEBI:50438 YesY
ChEMBL CHEMBL1465 YesY
ECHA InfoCard 100.006.464
Chemical and physical data
Formula C18H16O3
Molar mass 280.318 g/mol
3D model (Jmol) Interactive image
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Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism). It is the standard coumarin used in Germany.

Phenprocoumon is a 4-hydroxycoumarin and inhibits vitamin K epoxide reductase.[1]

References

  1. Phenprocoumon at PharmGKB


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