PUM2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3Q0Q, 3Q0R, 3Q0S

Identifiers

Aliases

PUM2, PUMH2, PUML2, pumilio RNA binding family member 2

External IDs

MGI: 1931751 HomoloGene: 69183 GeneCards: PUM2

Gene ontology
Molecular function	• poly(A) RNA binding • protein binding • RNA binding • mRNA 3'-UTR binding
Cellular component	• cytoplasm • perinuclear region of cytoplasm • cytoplasmic stress granule • nuclear membrane
Biological process	• regulation of chromosome segregation • regulation of gene silencing by miRNA • positive regulation of RIG-I signaling pathway • regulation of translation • regulation of mRNA stability • positive regulation of gene silencing by miRNA • stress granule assembly • posttranscriptional regulation of gene expression
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


23369


80913

Ensembl


ENSG00000055917


ENSMUSG00000020594

UniProt


Q8TB72


Q80U58

RefSeq (mRNA)


NM_001282752 NM_001282790 NM_001282791 NM_015317

NM_001160219 NM_001160220 NM_001160221 NM_001160222 NM_030723
NM_001310519

RefSeq (protein)


NP_001269681.1 NP_001269719.1 NP_001269720.1 NP_056132.1


NP_001153691.1 NP_001153694.1 NP_109648.2

Location (UCSC)

Chr 2: 20.25 – 20.35 Mb

Chr 12: 8.67 – 8.75 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Pumilio homolog 2 is an RNA-binding protein that in humans is encoded by the PUM2 gene.^[3]^[4]^[5]^[6]

Interactions

BRCA1 has been shown to interact with the following proteins:

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
↑ Spassov DS, Jurecic R (Dec 2002). "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins". Gene. 299 (1–2): 195–204. doi:10.1016/S0378-1119(02)01060-0. PMID 12459267.
↑ Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RA (Jan 2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins". Proc Natl Acad Sci U S A. 100 (2): 538–43. doi:10.1073/pnas.0234478100. PMC 141031. PMID 12511597.
↑ "Entrez Gene: PUM2 pumilio homolog 2 (Drosophila)".
↑ Campbell ZT, Menichelli E, Friend K, Wu J, Kimble J, Williamson JR, Wickens M (2012). "Identification of a conserved interface between PUF and CPEB proteins.". J Biol Chem. 287 (22): 18854–62. doi:10.1074/jbc.M112.352815. PMID 22496444.
↑ Ota R, Kotani T, Yamashita M (2011). "Biochemical characterization of Pumilio1 and Pumilio2 in Xenopus oocytes.". J Biol Chem. 286 (4): 2853–63. doi:10.1074/jbc.M110.155523. PMID 21098481.
↑ Haston KM, Tung JY, Reijo Pera RA (2009). "Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro.". PLOS ONE. 4 (5): e5654. doi:10.1371/journal.pone.0005654. PMC 2681483. PMID 19468308.
↑ Geyer CB, Saba R, Kato Y, Anderson AJ, Chappell VK, Saga Y, Eddy EM (2012). "Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male.". Biol Reprod. 86 (4): 127. doi:10.1095/biolreprod.111.094938. PMID 22190708.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Spik A, Oczkowski S, Olszak A, Kotecki M, Formanowicz P, Błazewicz J, Jaruzelska J (2006). "Candidate mRNAs interacting with fertility protein PUMILIO2 in the human germ line". Reproductive biology. 6 Suppl 1: 37–42. PMID 16967088.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Jaruzelska J, Kotecki M, Kusz K, Spik A, Firpo M, Reijo Pera RA (2004). "Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells". Dev. Genes Evol. 213 (3): 120–6. doi:10.1007/s00427-003-0303-2. PMID 12690449.
Dazard JE, Gal H, Amariglio N, Rechavi G, Domany E, Givol D (2003). "Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer". Oncogene. 22 (19): 2993–3006. doi:10.1038/sj.onc.1206537. PMID 12771951.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Fox M, Urano J, Reijo Pera RA (2005). "Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind". Genomics. 85 (1): 92–105. doi:10.1016/j.ygeno.2004.10.003. PMID 15607425.
Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW (2005). "P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA". J. Cell. Physiol. 204 (1): 99–105. doi:10.1002/jcp.20263. PMID 15617101.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kusz K, Ginter-Matuszewska B, Ziolkowska K, Spik A, Bierla J, Jedrzejczak P, Latos-Bielenska A, Pawelczyk L, Jaruzelska J (2007). "Polymorphisms of the human PUMILIO2 gene and male sterility". Mol. Reprod. Dev. 74 (6): 795–9. doi:10.1002/mrd.20683. PMID 17154300.

PDB gallery

1ib2: CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN

1m8w: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-19 RNA

1m8x: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-14 RNA

1m8y: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE2-10 RNA

1m8z: Crystal Structure Of A Pumilio-Homology Domain

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PUM2

Interactions

References

Further reading