PMEG (antiviral)
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| Names | |
|---|---|
| IUPAC name
2-(2-Amino-6-oxo-3H-purin-9-yl)ethoxymethylphosphonic acid | |
| Other names
9-((2-Phosphonylmethoxy)ethyl)guanine | |
| Identifiers | |
| 114088-58-3 | |
| 3D model (Jmol) | Interactive image |
| PubChem | 64989 |
| |
| |
| Properties | |
| C8H12N5O5P | |
| Molar mass | 289.19 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
PMEG is an antiviral that has been tested to treat certain types of herpes in mice.[1][2] GS-9191 and GS-9219 are PMEG pro-drugs.
References
- ↑ Kim, H. T.; Kim, D. K.; Kim, Y. W.; Kim, K. H.; Sugiyama, Y.; Kikuchi, M. (1995-11-01). "Antiviral activity of 9-[[(ethoxyhydroxyphosphinyl)-methoxy]methoxy] guanine against cytomegalovirus and herpes simplex virus". Antiviral Research. 28 (3): 243–251. ISSN 0166-3542. PMID 8629816.
- ↑ De Clercq, Erik (2013). "Dancing with chemical formulae of antivirals: A personal account". Biochemical Pharmacology. 86 (6): 711–25. doi:10.1016/j.bcp.2013.07.012. PMID 23876344.
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