PLEKHA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1EAZ

Identifiers

Aliases

PLEKHA1, TAPP1, pleckstrin homology domain containing A1

External IDs

MGI: 2442213 HomoloGene: 11001 GeneCards: PLEKHA1

Gene ontology
Molecular function	• PDZ domain binding • phosphatidylinositol-3,4-bisphosphate binding • protein binding • lipid binding
Cellular component	• cytoplasm • membrane • plasma membrane • nucleoplasm • ruffle membrane • extracellular exosome • nucleus
Biological process	• B cell receptor signaling pathway • palate development • negative regulation of protein kinase B signaling • luteinization • Leydig cell differentiation • estrogen metabolic process • androgen metabolic process • ruffle organization • multicellular organism growth • establishment of protein localization • skeletal system morphogenesis • post-embryonic development • female gonad development • spermatogenesis • phosphatidylinositol 3-kinase signaling • platelet-derived growth factor receptor signaling pathway • face morphogenesis • cellular response to hydrogen peroxide
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


59338


101476

Ensembl


ENSG00000107679


ENSMUSG00000040268

UniProt


Q9HB21


Q8BUL6

RefSeq (mRNA)


NM_001001974 NM_001195608 NM_021622


NM_133942

RefSeq (protein)


NP_001001974.1 NP_001182537.1 NP_067635.2


NP_598703.1

Location (UCSC)

Chr 10: 122.37 – 122.44 Mb

Chr 7: 130.87 – 130.91 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene.^[3]^[4]^[5]

Interactions

PLEKHA1 has been shown to interact with MPDZ.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
↑ Hogan A, Yakubchyk Y, Chabot J, Obagi C, Daher E, Maekawa K, Gee SH (Dec 2004). "The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization". J Biol Chem. 279 (51): 53717–24. doi:10.1074/jbc.M410654200. PMID 15485858.
↑ "Entrez Gene: PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1".
↑ Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (Feb 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM (2001). "Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity". Biochem. J. 358 (Pt 2): 287–94. doi:10.1042/0264-6021:3580287. PMC 1222060. PMID 11513726.
Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.
Marshall AJ, Krahn AK, Ma K, Duronio V, Hou S (2002). "TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor". Mol. Cell. Biol. 22 (15): 5479–91. doi:10.1128/MCB.22.15.5479-5491.2002. PMC 133950. PMID 12101241.
Kimber WA, Deak M, Prescott AR, Alessi DR (2003). "Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1". Biochem. J. 376 (Pt 2): 525–35. doi:10.1042/BJ20031154. PMC 1223793. PMID 14516276.
Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB (2006). "Susceptibility Genes for Age-Related Maculopathy on Chromosome 10q26". Am. J. Hum. Genet. 77 (3): 389–407. doi:10.1086/444437. PMC 1226205. PMID 16080115.

PDB gallery

1eaz: CRYSTAL STRUCTURE OF THE PHOSPHOINOSITOL (3,4)-BISPHOSPHATE BINDING PH DOMAIN OF TAPP1 FROM HUMAN.

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PLEKHA1

Interactions

References

Further reading