PLEK2
Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.[3][4][5] The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.[6]
References
Further reading
- Bach TL, Kerr WT, Wang Y, et al. (2007). "PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.". Blood. 109 (3): 1147–55. doi:10.1182/blood-2006-02-001339. PMC 1785144
. PMID 17008542.
- Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K (2005). "Cloning, expression and chromosomal assignment of human pleckstrin 2.". Mol. Biol. Rep. 32 (1): 35–40. doi:10.1007/s11033-004-4747-x. PMID 15865208.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Inazu T, Yamada K, Miyamoto K (1999). "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family.". Biochem. Biophys. Res. Commun. 265 (1): 87–93. doi:10.1006/bbrc.1999.1461. PMID 10548495.
- Hu MH, Bauman EM, Roll RL, et al. (1999). "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement.". J. Biol. Chem. 274 (31): 21515–8. doi:10.1074/jbc.274.31.21515. PMID 10419454.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
PDB gallery |
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| 1v3f: Solution structure of the DEP domain of mouse pleckstrin2 |
| 1x1g: Solution structure of the C-terminal PH domain of human pleckstrin 2 |
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