PHF12

PHF12

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2L9S, 2LKM

Identifiers

PHF12, PF1, PHD finger protein 12

External IDs

MGI: 1924057 HomoloGene: 10841 GeneCards: PHF12

Gene ontology
Molecular function	• transcription corepressor binding • histone binding • zinc ion binding • RNA polymerase II transcription corepressor activity • RNA polymerase II regulatory region sequence-specific DNA binding • chromatin binding • protein binding • phosphatidylinositol binding • metal ion binding
Cellular component	• transcriptional repressor complex • Sin3 complex • nucleus • nucleoplasm
Biological process	• negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


57649


268448


ENSG00000109118


ENSMUSG00000037791


Q96QT6


Q5SPL2

RefSeq (mRNA)


NM_001033561 NM_001290131 NM_020889


NM_174852

RefSeq (protein)


NP_001028733.1 NP_001277060.1 NP_065940.1


NP_777277.2

Location (UCSC)

Chr 17: 28.91 – 28.95 Mb

Chr 11: 77.98 – 78.03 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene.^[3]^[4]

Interactions

PHF12 has been shown to interact with SIN3A.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Yochum GS, Ayer DE (Jun 2001). "Pf1, a Novel PHD Zinc Finger Protein That Links the TLE Corepressor to the mSin3A-Histone Deacetylase Complex". Mol Cell Biol. 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.
↑ "Entrez Gene: PHF12 PHD finger protein 12".

Further reading

Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

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