PEX13

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WXU

Identifiers

Aliases

PEX13, NALD, PBD11A, PBD11B, ZWS, peroxisomal biogenesis factor 13

External IDs

MGI: 1919379 HomoloGene: 1967 GeneCards: PEX13

Gene ontology
Molecular function	• protein binding
Cellular component	• peroxisome • peroxisomal membrane • membrane • integral component of peroxisomal membrane • intracellular membrane-bounded organelle • integral component of membrane
Biological process	• positive regulation of defense response to virus by host • cerebral cortex cell migration • protein transport • suckling behavior • fatty acid alpha-oxidation • microtubule-based peroxisome localization • locomotory behavior • transport • xenophagy • protein import into peroxisome matrix, docking • neuron migration
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5194


72129

Ensembl


ENSG00000162928


ENSMUSG00000020283

UniProt


Q92968


Q9D0K1

RefSeq (mRNA)


NM_002618


NM_023651

RefSeq (protein)


NP_002609.1


NP_076140.2

Location (UCSC)

Chr 2: 61.02 – 61.05 Mb

Chr 11: 23.65 – 23.67 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene.^[3]^[4] It located on chromosome 2 next to KIAA1841

Interactions

PEX13 has been shown to interact with PEX14,^[5] PEX5^[5]^[6] and PEX19.^[7]^[8]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bjorkman J, Stetten G, Moore CS, Gould SJ, Crane DI (February 1999). "Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene". Genomics. 54 (3): 521–8. doi:10.1006/geno.1998.5520. PMID 9878256.
↑ "Entrez Gene: PEX13 peroxisome biogenesis factor 13".
1 2 Otera, Hidenori; Setoguchi Kiyoko; Hamasaki Maho; Kumashiro Toshitaka; Shimizu Nobuhiro; Fujiki Yukio (March 2002). "Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import". Mol. Cell. Biol. United States. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. ISSN 0270-7306. PMC 135613. PMID 11865044.
↑ Gould, S J; Kalish J E; Morrell J C; Bjorkman J; Urquhart A J; Crane D I (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". J. Cell Biol. UNITED STATES. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. ISSN 0021-9525. PMC 2121023. PMID 8858165.
↑ Sacksteder, K A; Jones J M; South S T; Li X; Liu Y; Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. UNITED STATES. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444.
↑ Fransen, M; Wylin T; Brees C; Mannaerts G P; Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. United States. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669.

Gould SJ, Kalish JE, Morrell JC, et al. (1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". J. Cell Biol. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165.
Albertini M, Rehling P, Erdmann R, et al. (1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways". Cell. 89 (1): 83–92. doi:10.1016/S0092-8674(00)80185-3. PMID 9094717.
Fransen M, Terlecky SR, Subramani S (1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8087–92. doi:10.1073/pnas.95.14.8087. PMC 20933. PMID 9653144.
Girzalsky W, Rehling P, Stein K, et al. (1999). "Involvement of Pex13p in Pex14p Localization and Peroxisomal Targeting Signal 2–dependent Protein Import into Peroxisomes". J. Cell Biol. 144 (6): 1151–62. doi:10.1083/jcb.144.6.1151. PMC 2150583. PMID 10087260.
Shimozawa N, Suzuki Y, Zhang Z, et al. (1999). "Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders". Hum. Mol. Genet. 8 (6): 1077–83. doi:10.1093/hmg/8.6.1077. PMID 10332040.
Toyama R, Mukai S, Itagaki A, et al. (2000). "Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants". Hum. Mol. Genet. 8 (9): 1673–81. doi:10.1093/hmg/8.9.1673. PMID 10441330.
Liu Y, Björkman J, Urquhart A, et al. (1999). "PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders". Am. J. Hum. Genet. 65 (3): 621–34. doi:10.1086/302534. PMC 1377968. PMID 10441568.
Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
Fransen M, Wylin T, Brees C, et al. (2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
Jones JM, Morrell JC, Gould SJ (2001). "Multiple Distinct Targeting Signals in Integral Peroxisomal Membrane Proteins". J. Cell Biol. 153 (6): 1141–50. doi:10.1083/jcb.153.6.1141. PMC 2192020. PMID 11402059.
Otera H, Setoguchi K, Hamasaki M, et al. (2002). "Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import". Mol. Cell. Biol. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fransen M, Vastiau I, Brees C, et al. (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". J. Biol. Chem. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hashimoto K, Kato Z, Nagase T, et al. (2005). "Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder". Pediatr. Res. 58 (2): 263–9. doi:10.1203/01.PDR.0000169984.89199.69. PMID 16006427.
Nguyen T, Bjorkman J, Paton BC, Crane DI (2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance". J. Cell. Sci. 119 (Pt 4): 636–45. doi:10.1242/jcs.02776. PMID 16449325.

External links

PDB gallery

1wxu: Solution structure of the SH3 domain of mouse peroxisomal biogenesis factor 13

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PEX13

Interactions

References

Further reading

External links