Nitarsone

Nitarsone

Names
IUPAC name (4-Nitrophenyl)arsonic acid
Other names (p-Nitrophenyl)arsonic acid; 4-Nitrobenzenearsonic acid
Identifiers
CAS Number	98-72-6
3D model (Jmol)	Interactive image
ChemSpider	60190
ECHA InfoCard	100.002.451
PubChem	66826
InChI InChI=1S/C6H6AsNO5/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4H,(H2,9,10,11) Key: FUUFQLXAIUOWML-UHFFFAOYSA-N InChI=1/C6H6AsNO5/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4H,(H2,9,10,11) Key: FUUFQLXAIUOWML-UHFFFAOYAA
SMILES O=[N+]([O-])c1ccc(cc1)[As](=O)(O)O
Properties
Chemical formula	C6H6AsNO5
Molar mass	247.04 g·mol−1
Melting point	298–300 °C (568–572 °F; 571–573 K) (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Nitarsone is an organoarsenic compound that is used in poultry production as a feed additive to increase weight gain, improve feed efficiency, and prevent blackhead disease.^[1] It is marketed as Histostat by Zoetis, a publicly traded subsidiary of Pfizer.^[2]

Nitarsone is one of four arsenical animal drugs approved by the U.S. Food and Drug Administration for use in poultry, along with roxarsone, arsanilic acid, and carbarsone.^[3] Following the 2011 suspension of roxarsone sales in the United States, however, it is believed to be the only arsenical animal drug currently marketed in the U.S.^[3][4] In September 2013, the FDA announced that Zoetis and Fleming Laboratories would voluntarily withdraw current roxarsone, arsanilic acid, and carbarsone approvals, leaving only nitarsone approvals in place.^[5] When the withdrawals occurred, nitarsone was only arsenical approved for use in food animals in the U.S. In 2015 FDA withdrew the approval of using nitarsone in animal feeds. The ban came into effect at the end of 2015.^[6]

References