Niperotidine

Niperotidine

Names
IUPAC name (Z)-1-N'-(1,3-benzodioxol-5-ylmethyl)-1-N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-2-nitroethene-1,1-diamine
Identifiers
CAS Number	84845-75-0 Y
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL1909284 N
ChemSpider	11644617 N
ECHA InfoCard	100.076.612
EC Number	284-304-0
KEGG	D07072 Y
MeSH	C073716
PubChem	3033952
UNII	12JBD7U72K Y
InChI InChI=1S/C20H28N4O5S/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18/h3-6,9,20-22H,7-8,10-14H2,1-2H3 N Key: VZPXHGJTEAPNAA-UHFFFAOYSA-N N InChI=1/C20H28N4O5S/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18/h3-6,9,20-22H,7-8,10-14H2,1-2H3 Key: VZPXHGJTEAPNAA-UHFFFAOYAQ
SMILES CN(C)Cc1ccc(o1)CSCCN(=C[N+](=O)[O-])NCc2cc3OCOc3cc2
Properties
Chemical formula	C20H26N4O5S
Molar mass	434.50924 g/mol
Pharmacology
ATC code	A02BA05 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Niperotidine is a histamine antagonist selective for the H₂ subtype. It was trialled as a treatment for excessive gastric acidity,^[1] but withdrawn after human trials showed liver damage.^[2]

References

1. ↑ Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Italian Journal of Gastroenterology. 1990 Oct;22(5):291-4. PMID 1983712
2. ↑ Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 1997 Sep;27(3):583-6. PMID 9314138