Methallenestril
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| Clinical data | |
|---|---|
| ATC code |
G03CB03 (WHO) G03CC03 (WHO) |
| Identifiers | |
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| Synonyms | β-Ethyl-6-methoxy-α,α-dimethyl-2-naphthalenepropionic acid |
| CAS Number | 517-18-0 |
| PubChem (CID) | 10599 |
| ChemSpider | 10154 |
| ECHA InfoCard | 100.007.485 |
| Chemical and physical data | |
| Formula | C18H22O3 |
| Molar mass | 286.365 g/mol |
| 3D model (Jmol) | Interactive image |
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Methallenestril (INN) (brand names Cur-men, Ercostrol, Geklimon, Novestrine, Vallestril), also known as methallenoestril (BAN) and as methallenestrol, as well as Horeau's acid and dimethylethylallenolic acid,[1][2] is a synthetic, non-steroidal estrogen derived from allenolic acid that was formerly used to treat menstrual issues but is now no longer marketed.[3][4][5][6] It is a seco-analogue of bisdehydrodoisynolic acid, and although methallenestril is potently estrogenic in rats, in humans it is only weakly so in comparison.[7] Vallestril was a brand of methallenestril issued by G. D. Searle & Company in the 1950s.[8]
See also
- Fenestrel
- Carbestrol
- Doisynoestrol
- Chlorotrianisene
- Triphenylethylene
- Diethylstilbestrol
- Stilbestrol
- Ethamoxytriphetol
References
- ↑ Erich Heftmann (1970). Steroid Biochemistry. Academic Press. p. 144.
- ↑ Dodds, E. C. (1949). "Synthetic aestrogens". Journal of Pharmacy and Pharmacology. 1 (1): 137–147. doi:10.1111/j.2042-7158.1949.tb12391.x. ISSN 0022-3573.
- ↑ C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1295–. ISBN 978-0-412-46630-4.
- ↑ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 177–. ISBN 978-94-011-4439-1.
- ↑ John A. Thomas; Edward J. Keenan (1986). Principles of Endocrine Pharmacology. Springer Science & Business Media. pp. 171–. ISBN 978-1-4684-5036-1.
- ↑ Herbai G, Ljunghall S (1983). "Normalization of hypercalcaemia of primary hyperparathyroidism by treatment with methallenestril, a synthetic oestrogen with low oestrogenicity". Urol. Int. 38 (6): 371–3. doi:10.1159/000280925. PMID 6659184.
- ↑ Raymond Eller Kirk; Donald Frederick Othmer (1980). Encyclopedia of chemical technology. Wiley. p. 670. ISBN 978-0-471-02065-3.
- ↑ Library of Congress. Copyright Office (1965). Catalog of Copyright Entries. Third Series: 1963: July-December. Copyright Office, Library of Congress. pp. 1984–.
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