Mesulfen

Mesulfen
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	D10AB05 (WHO) P03AA03 (WHO) QP53AA01 (WHO)
Identifiers
IUPAC name 2,8-dimethylthianthrene
CAS Number	135-58-0^Y
PubChem (CID)	67272
ChemSpider	580870
UNII	EG6V6W7WDD^Y
KEGG	D07212^Y
ECHA InfoCard	100.004.730
Chemical and physical data
Formula	C₁₄H₁₂S₂
Molar mass	244.37508 g/mol
3D model (Jmol)	Interactive image
SMILES CC1=CC2=C(C=C1)SC3=C(S2)C=C(C=C3)C
InChI InChI=1S/C14H12S2/c1-9-3-5-11-13(7-9)15-12-6-4-10(2)8-14(12)16-11/h3-8H,1-2H3 Key:AHXDSVSZEZHDLV-UHFFFAOYSA-N
(verify)

Mesulfen is an anti-acne preparation^[1] as well as a scabicide.^[2] It is a dimethyl derivative of thianthrene.

References

↑ Leoni, A.; Dudine, G. (1983). "Therapy of seborrhea, seborrheic eczema and acne with a soap with a mesulfen base". Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia. 118 (2): XXI–XXIV. PMID 6226594.
↑ Meneghini, C. L.; Vena, G. A.; Angelini, G. (1982). "Contact dermatitis to scabicides". Contact dermatitis. 8 (4): 285–286. doi:10.1111/j.1600-0536.1982.tb04231.x. PMID 7105702.

Acne-treating agents (D10)

Antibacterial	Azelaic acid Benzoyl peroxide^# 8-Hydroxyquinoline Blue light therapy Tea tree oil

Keratolytic	Glycolic acid Salicylic acid^# Sulfur Benzoyl peroxide^#

Anti-inflammatory	Nicotinamide Ibuprofen # Aspirin # Red light therapy

Antibiotics	Clindamycin Dapsone Erythromycin Sulfacetamide Tetracyclines (Lymecycline Minocycline Doxycycline)

Hormonal	Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone) Estrogens Estradiol Ethinyl estradiol

Retinoids	Adapalene Isotretinoin Motretinide Tazarotene Tretinoin

Other	Benzamycin Epristeride Mesulfen Pelretin Stridex Tioxolone

Combinations	Adapalene/benzoyl peroxide Benzoyl peroxide/clindamycin Clindamycin/tretinoin Erythromycin/isotretinoin Sulfacetamide/sulfur

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Chlorine-containing products	Lindane

Chloride channel	Ivermectin

Organophosphate	Malathion

Pyrethrines	Permethrin^# Pyrethrum Phenothrin Bioallethrin

Chloride channel	Ivermectin

Sulfur-containing products	Disulfiram Dixanthogen Mesulfen Thiram

Chlorine-containing products	Lindane

Benzoate	Benzyl benzoate^#

Organophosphate	Malathion

Other/ungrouped	Dimethicone Quassia toluidine (Crotamiton)

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