Mestilbol
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| Identifiers | |
|---|---|
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| Synonyms | Monomethylstilbestrol |
| CAS Number | 18839-90-2 |
| PubChem (CID) | 3032340 |
| ChemSpider | 2297337 |
| UNII | N44U12UW5N |
| ChEBI | CHEBI:34702 |
| Chemical and physical data | |
| Formula | C19H22O2 |
| Molar mass | 282.37678 g/mol |
| 3D model (Jmol) | Interactive image |
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Mestilbol (brand name Monomestro or Monomestrol), also known as diethylstilbestrol monomethyl ether, is a synthetic, non-steroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1][2][3] It was developed by Wallace & Tiernan Company,[3] patented in 1940,[4] and introduced for medical use in the 1940s,[5] but is now no longer marketed. Mestilbol was available both as oral tablets and in oil for intramuscular injection.[3][6] The drug is gradually demethylated in the body into diethylstilbestrol and hence is a prodrug of diethylstilbestrol.[7] Mestilbol is a highly active estrogen,[6] although somewhat less so than diethylstilbestrol,[8] but is longer-lasting in comparison.[9]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 396. ISBN 978-1-4757-2085-3.
- ↑ Martin Negwer (1987). Organic-chemical drugs and their synonyms: (an international survey). VCH Publishers. p. 923. ISBN 978-0-89573-552-2.
- 1 2 3 Council on Drugs (American Medical Association) (1955). New and Nonofficial Drugs. Lippincott. pp. 419–420.
- ↑ http://www.google.com.na/patents/US2385468
- ↑ Sevringhaus, Elmer L. (1944). "Therapy of the Patient in the Menopause: Endocrine Methods". The Journal of Clinical Endocrinology & Metabolism. 4 (12): 597–604. doi:10.1210/jcem-4-12-597. ISSN 0021-972X.
- 1 2 Postgraduate Medicine. McGraw-Hill. 1949. p. 347.
- ↑ Annales de Bourgogne. Centre d'études bourguignonnes. 1940.
- ↑ Russell La Fayette Cecil; Robert Frederick Loeb (1951). A Textbook of Medicine. Saunders.
- ↑ William Thomas Salter (1952). A Textbook of Pharmacology: Principles and Application of Pharmacology to the Practice of Medicine. Saunders.
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