Meglumine antimoniate

Meglumine antimoniate
Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	P01CB01 (WHO) QP51AB01 (WHO)
Identifiers
IUPAC name Hydroxy-dioxostiborane; (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol
CAS Number	133-51-7^N
PubChem (CID)	64953
ChemSpider	58479^Y
UNII	75G4TW236W^N
ChEMBL	CHEMBL239129^Y
NIAID ChemDB	008733
ECHA InfoCard	100.004.645
Chemical and physical data
Formula	Variable
Molar mass	Variable
3D model (Jmol)	Interactive image
SMILES O=[Sb](=O)O.O[C@@H]([C@@H](O)[C@H](O)[C@@H](O)CNC)CO
InChI InChI=1S/C7H17NO5.H2O.2O.Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;;;;/h4-13H,2-3H2,1H3;1H2;;;/q;;;;+1/p-1/t4-,5+,6+,7+;;;;/m0..../s1^Y Key:XOGYVDXPYVPAAQ-SESJOKTNSA-M^Y
^NY (what is this?) (verify)

Meglumine antimoniate (or meglumine antimonate) is a medicine used for treating leishmaniasis.^[1] It is manufactured by Aventis^[2] and sold as Glucantime in France, and Glucantim in Italy. It belongs to a group of compounds known as the pentavalent antimonials. It is administered by intramuscular injection.

References

↑ Soto, J.; Fuya, P.; Herrera, R.; Berman, J. (1998). "Topical paromomycin/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment for American cutaneous leishmaniasis: Controlled study". Clinical Infectious Diseases. 26 (1): 56–58. doi:10.1086/516267. PMID 9455509.
↑ Aventis press release, 15 April 2005. (German)

Trypanosomiasis	African trypanosomiasis: ornithine (Eflornithine^#) arsenical (Melarsoprol^#) benzamidine (Pentamidine^#) naphthalenesulfonate (Suramin^#) nitroimidazole (Fexinidazole^†) Chagas disease: nitroimidazole (Benznidazole^#) nitrofuran (Nifurtimox^#)

Leishmaniasis	macrolide (Amphotericin B^#) Pentavalent antimonials (Meglumine antimoniate^#, Sodium stibogluconate) benzamidine (Pentamidine^#) phosphorylcholine (Miltefosine) neomycin (Paromomycin)

PAM	macrolide (Amphotericin B)

Giardiasis	nitroimidazole (Metronidazole^#, Tinidazole) benzimidazole (Albendazole) thiazolide (Nitazoxanide) nitrofuran (Furazolidone) aminoacridine (Quinacrine)

Trichomoniasis	nitroimidazole (Carnidazole, Metronidazole^#, Tinidazole)

Dientamoebiasis	nitroimidazole (Metronidazole Secnidazole) oxyquinoline (Iodoquinol) tetracycline (Doxycycline) neomycin (Paromomycin)

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