MXD1

MXD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E91, 1G1E, 1NLW, 1PD7, 1S5Q
Identifiers
Aliases	MXD1, BHLHC58, MAD, MAD1, MAX dimerization protein 1
External IDs	MGI: 96908 HomoloGene: 1767 GeneCards: MXD1
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcription cofactor activity • protein dimerization activity • transcription corepressor activity Cellular component • nuclear chromatin • nucleus Biological process • multicellular organism development • cell proliferation • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4084	17119
Ensembl	ENSG00000059728	ENSMUSG00000001156
UniProt	Q05195	P50538
RefSeq (mRNA)	NM_002357 NM_001202513 NM_001202514	NM_010751
RefSeq (protein)	NP_001189442.1 NP_001189443.1 NP_002348.1	n/a
Location (UCSC)	Chr 2: 69.9 – 69.94 Mb	Chr 6: 86.65 – 86.67 Mb
PubMed search	[1]	[2]
Wikidata

MAD protein is a protein that in humans is encoded by the MXD1 gene.^[3][4]

MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.^[4] The MAD-MAX protein dimer may be a reference to the popular cult classic film Mad Max (1979).

Interactions

MXD1 has been shown to interact with Histone deacetylase 2,^[5][6] SMC3,^[7] MLX,^[8][9] SIN3A^[10][11][12] and MAX.^{[7][13][14][15]}

References

Further reading