MRK-016
 | |
| Names | |
|---|---|
| IUPAC name
3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)pyrazolo(1,5-d)(1,2,4)triazine | |
| Identifiers | |
| 783331-24-8 | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 5293780 |
| |
| Properties | |
| C17H20N8O2 | |
| Molar mass | 368.40 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
MRK-016 is a selective α5 subunit-containing GABAA negative allosteric modulator that has nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression.[1]
See also
References
- ↑ Fischell, Jonathan; Van Dyke, Adam M; Kvarta, Mark D; LeGates, Tara A; Thompson, Scott M (2015). "Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors". Neuropsychopharmacology. doi:10.1038/npp.2015.112. ISSN 0893-133X.
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