MLF1

MLF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3UAL, 3UBW

Identifiers

External IDs

MGI: 1341819 HomoloGene: 7839 GeneCards: MLF1

Gene ontology
Molecular function	• DNA binding • protein binding • protein domain specific binding
Cellular component	• cytoplasm • nucleus
Biological process	• multicellular organism development • cell cycle • cell differentiation • myeloid progenitor cell differentiation • cell cycle arrest • transcription, DNA-templated
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


4291


17349


ENSG00000178053


ENSMUSG00000048416


P58340


Q9QWV4

RefSeq (mRNA)

NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434
NM_022443


NM_001039543 NM_010801

RefSeq (protein)

NP_001123628.1 NP_001123629.1 NP_001182361.1 NP_001182362.1 NP_001182363.1
NP_071888.1


NP_034931.2

Location (UCSC)

Chr 3: 158.57 – 158.61 Mb

Chr 3: 67.37 – 67.4 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Myeloid leukemia factor 1 is a protein that in humans is encoded by the MLF1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW (Mar 1996). "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Oncogene. 12 (2): 265–75. PMID 8570204.
↑ "Entrez Gene: MLF1 myeloid leukemia factor 1".

Further reading

Lim R, Winteringham LN, Williams JH, et al. (2002). "MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.". J. Biol. Chem. 277 (43): 40997–1008. doi:10.1074/jbc.M206041200. PMID 12176995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Arber DA, Chang KL, Lyda MH, et al. (2003). "Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia.". Hum. Pathol. 34 (8): 809–13. doi:10.1016/S0046-8177(03)00251-X. PMID 14506644.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hanissian SH, Akbar U, Teng B, et al. (2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yoneda-Kato N, Tomoda K, Umehara M, et al. (2005). "Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.". EMBO J. 24 (9): 1739–49. doi:10.1038/sj.emboj.7600656. PMC 1142586. PMID 15861129.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Yoneda-Kato N, Kato JY (2008). "Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation.". Mol. Cell. Biol. 28 (1): 422–34. doi:10.1128/MCB.02335-06. PMC 2223285. PMID 17967869.

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