MAGEA1

MAGEA1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1W72, 3BO8
Identifiers
Aliases	MAGEA1, CT1.1, MAGE1, MAGE family member A1
External IDs	HomoloGene: 88717 GeneCards: MAGEA1
Gene ontology Molecular function • histone deacetylase binding • protein binding Cellular component • cytoplasm • plasma membrane • nucleus Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4100	n/a
Ensembl	ENSG00000198681	n/a
UniProt	P43355	n/a
RefSeq (mRNA)	NM_004988	n/a
RefSeq (protein)	NP_004979.3	n/a
Location (UCSC)	Chr X: 153.18 – 153.18 Mb	n/a
PubMed search	[1]	n/a
Wikidata

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.^[2]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[3]

References

Further reading