Lupeol synthase
| Lupeol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.41 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Lupeol synthase (EC 5.4.99.41, LUPI, BPW, RcLUS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (3S)-2,3-epoxy-2,3-dihydrosqualene lupeol
Also forms some beta-amyrin.
References
- ↑ Herrera, J.B.; Bartel, B.; Wilson, W.K.; Matsuda, S.P. (1998). "Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene". Phytochemistry. 49: 1905–1911. doi:10.1016/s0031-9422(98)00366-5. PMID 9883589.
- ↑ Shibuya, M.; Zhang, H.; Endo, A.; Shishikura, K.; Kushiro, T.; Ebizuka, Y. (1999). "Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases". Eur. J. Biochem. 266: 302–307. doi:10.1046/j.1432-1327.1999.00875.x. PMID 10542078.
- ↑ Segura, M.J.; Meyer, M.M.; Matsuda, S.P. (2000). "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Org. Lett. 2: 2257–2259. doi:10.1021/ol006016b. PMID 10930257.
- ↑ Zhang, H.; Shibuya, M.; Yokota, S.; Ebizuka, Y. (2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biol. Pharm. Bull. 26: 642–650. doi:10.1248/bpb.26.642. PMID 12736505.
- ↑ Hayashi, H.; Huang, P.; Takada, S.; Obinata, M.; Inoue, K.; Shibuya, M.; Ebizuka, Y. (2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biol. Pharm. Bull. 27: 1086–1092. doi:10.1248/bpb.27.1086. PMID 15256745.
- ↑ Guhling, O.; Hobl, B.; Yeats, T.; Jetter, R. (2006). "Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis". Arch. Biochem. Biophys. 448: 60–72. doi:10.1016/j.abb.2005.12.013. PMID 16445885.
- ↑ Basyuni, M.; Oku, H.; Tsujimoto, E.; Kinjo, K.; Baba, S.; Takara, K. (2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". FEBS J. 274: 5028–5042. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686.
External links
- Lupeol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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