LCP1
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Plastin-2 is a protein that in humans is encoded by the LCP1 gene.[4]
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.[5]
References
- ↑ "Diseases that are genetically associated with LCP1 view/edit references on wikidata".
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (Jun 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry. 29 (4): 1055–62. doi:10.1021/bi00456a030. PMID 2111166.
- ↑ "Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)".
Further reading
- Namba Y, Ito M, Zu Y, et al. (1993). "Human T cell L-plastin bundles actin filaments in a calcium-dependent manner.". J. Biochem. 112 (4): 503–7. PMID 1491005.
- Zu YL, Shigesada K, Nishida E, et al. (1991). "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites.". Biochemistry. 29 (36): 8319–24. doi:10.1021/bi00488a017. PMID 2252891.
- Lin CS, Aebersold RH, Leavitt J (1990). "Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain.". Mol. Cell. Biol. 10 (4): 1818–21. PMC 362293
. PMID 2378651. - Lin CS, Aebersold RH, Kent SB, et al. (1989). "Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.". Mol. Cell. Biol. 8 (11): 4659–68. PMC 365555. PMID 3211125.
- Matsushima K, Shiroo M, Kung HF, Copeland TD (1988). "Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1.". Biochemistry. 27 (10): 3765–70. doi:10.1021/bi00410a037. PMID 3261603.
- Kondo I, Shin K, Honmura S, et al. (1986). "A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13.". Hum. Genet. 71 (3): 263–6. doi:10.1007/BF00284588. PMID 3864729.
- Arpin M, Friederich E, Algrain M, et al. (1995). "Functional differences between L- and T-plastin isoforms.". J. Cell Biol. 127 (6 Pt 2): 1995–2008. doi:10.1083/jcb.127.6.1995. PMC 2120298. PMID 7806577.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Lin CS, Shen W, Chen ZP, et al. (1994). "Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney.". Mol. Cell. Biol. 14 (4): 2457–67. doi:10.1128/mcb.14.4.2457. PMC 358613. PMID 8139549.
- Lin CS, Park T, Chen ZP, Leavitt J (1993). "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.". J. Biol. Chem. 268 (4): 2781–92. PMID 8428952.
- Lin CS, Chen ZP, Park T, et al. (1993). "Characterization of the human L-plastin gene promoter in normal and neoplastic cells.". J. Biol. Chem. 268 (4): 2793–801. PMID 8428953.
- Jones SL, Brown EJ (1996). "FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils.". J. Biol. Chem. 271 (24): 14623–30. doi:10.1074/jbc.271.24.14623. PMID 8663066.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Okumura Y, Yano M, Murakami M, et al. (1999). "The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin.". FEBS Lett. 442 (1): 39–42. doi:10.1016/S0014-5793(98)01612-3. PMID 9923600.
- Wang J, Brown EJ (1999). "Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A.". J. Biol. Chem. 274 (34): 24349–56. doi:10.1074/jbc.274.34.24349. PMID 10446213.
- Lin CS, Lau A, Yeh CC, et al. (2000). "Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences.". DNA Cell Biol. 19 (1): 1–7. doi:10.1089/104454900314654. PMID 10668786.
- Jia J, Han Q, Borregaard N, et al. (2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.". J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
- Lollike K, Johnsen AH, Durussel I, et al. (2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner.". J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
- Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
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