KLRA1
| killer cell lectin-like receptor, subfamily A, member 2 | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | Klra2 |
| Alt. symbols | Ly49b; Klra30 |
| Entrez | 16633 |
| RefSeq (mRNA) | NM_008462.5 |
| RefSeq (Prot) | NP_032488.4 |
| UniProt | Q60660 |
| Other data | |
| Chromosome | 6: 131.22 - 131.25 Mb |
| Killer cell lectin-like receptor subfamily A pseudogene 1 | |
|---|---|
| Identifiers | |
| Symbol | KLRAP1 |
| Alt. symbols | KLRA1; Ly49; LY49L; Ly-49L |
| Entrez | 10748 |
| HUGO | 6372 |
| OMIM | 604274 |
| RefSeq | NM_006611 |
| UniProt | O75889 |
| Other data | |
| Locus | Chr. 12 p12-p13 |
Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor.[1][2] Ly-49 proteins are a diverse set of C-type lectins that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host MHC class I as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit cytotoxic T cell mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.
The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).[3][4]
References
- ↑ Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S (January 2005). "The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex". Eur. J. Immunol. 35 (1): 261–72. doi:10.1002/eji.200425429. PMID 15593300.
- ↑ Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG (November 2006). "Ly49B is expressed on multiple subpopulations of myeloid cells". J. Immunol. 177 (9): 5840–51. doi:10.4049/jimmunol.177.9.5840. PMID 17056508.
- ↑ Barten R, Trowsdale J (July 1999). "The human Ly-49L gene". Immunogenetics. 49 (7-8): 731–4. doi:10.1007/s002510050675. PMID 10369937.
- ↑ Hao L, Klein J, Nei M (February 2006). "Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals". Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3192–7. doi:10.1073/pnas.0511280103. PMC 1413923
. PMID 16492762.
External links
- Ly-49 antigen at the US National Library of Medicine Medical Subject Headings (MeSH)