Julie Ahringer

Dr. Julie Ahringer
Born Julie Ann Ahringer
Fields

Developmental Biology Genomics

Genetics
Institutions Gurdon Institute
University of Cambridge
Laboratory of Molecular Biology
University of Wisconsin–Madison
Alma mater University of Wisconsin–Madison
Thesis Post-transcriptional regulation of fem-3, a sex-determining gene of Caenorhabditis elegans (1991)
Doctoral advisor Judith Kimble
Known for RNA interference[1]
Caenorhabditis elegans[2][3][4][5][6]
Notable awards EMBO member (2003)
FMedSci (2007)
Crick Lecture (2004)
Spouse Richard Durbin[7]
Website
www2.gurdon.cam.ac.uk/~ahringerlab
www.gurdon.cam.ac.uk/ahringer.html

Dr. Julie Ann Ahringer FMedSci is a Professor of Genetics and Genomics, and a Wellcome Trust Senior Research Fellow at the Gurdon Institute and Department of Genetics, University of Cambridge.[8][9][10][11] She leads a research lab investigating the control of gene expression.

Education

Ahringer completed her PhD at the University of Wisconsin–Madison while working with Judith Kimble.[12][13][14] She carried out postdoctoral research at the MRC Laboratory of Molecular Biology in Cambridge with John White.[15]

Research

Ahringer became a group leader in the Department of Genetics in Cambridge in 1996, then moved to the Gurdon Institute in 1998. Her laboratory carried out the first systematic inactivation of the majority of genes in any animal by constructing and screening a genome-wide RNAi library for Caenorhabditis elegans. Ahringer's current research group studies the regulation of chromatin structure and function in gene expression and genome organization using the nematode C. elegans as a model to understand development and disease. The Ahringer Lab research is funded by the Wellcome Trust.[16]

Honours and awards

Ahringer was elected a member of European Molecular Biology Organization (EMBO) in 2003 and a Fellow of the Academy of Medical Sciences in 2007, and she delivered the Francis Crick lecture prize of the Royal Society in 2004.[17] She is the member of the Scientific Advisory Board along with many other eminent scientists[18]

Personal life

Ahringer is married to Richard Durbin, with whom she has two children.[7]

References

  1. ↑ Qu, W.; Ren, C.; Li, Y.; Shi, J.; Zhang, J.; Wang, X.; Hang, X.; Lu, Y.; Zhao, D.; Zhang, C. (2011). "Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: A guide for genome-wide screens". BMC Genomics. 12: 170. doi:10.1186/1471-2164-12-170. PMC 3087708Freely accessible. PMID 21453524.
  2. ↑ Kamath, R.; Fraser, A.; Dong, Y.; Poulin, G.; Durbin, R.; Gotta, M.; Kanapin, A.; Le Bot, N.; Moreno, S.; Sohrmann, M.; Welchman, D. P.; Zipperlen, P.; Ahringer, J. (2003). "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi". Nature. 421 (6920): 231–237. doi:10.1038/nature01278. PMID 12529635.
  3. ↑ Ahringer, J.; Kamath, A. G.; Zipperlen, R. S.; Martinez-Campos, P.; Sohrmann, M.; Ahringer, M. (2000). "Functional genomic analysis of C. Elegans chromosome I by systematic RNA interference". Nature. 408 (6810): 325–330. doi:10.1038/35042517. PMID 11099033.
  4. ↑ Murphy, C. T.; McCarroll, S. A.; Bargmann, C. I.; Fraser, A.; Kamath, R. S.; Ahringer, J.; Li, H.; Kenyon, C. (2003). "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans". Nature. 424 (6946): 277–283. doi:10.1038/nature01789. PMID 12845331.
  5. ↑ Ashrafi, K.; Chang, F. Y.; Watts, J. L.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2003). "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes". Nature. 421 (6920): 268–272. doi:10.1038/nature01279. PMID 12529643.
  6. ↑ Lee, S. S.; Lee, R. Y. N.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2002). "A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity". Nature Genetics. 33 (1): 40–48. doi:10.1038/ng1056. PMID 12447374.
  7. 1 2 "DURBIN, Richard Michael". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press.(subscription required)
  8. ↑ Ahringer Lab. "The regulation of chromatin structure in c Elegans".
  9. ↑ Julie Ahringer's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  10. ↑ List of publications from Microsoft Academic Search
  11. ↑ Pocock, R.; Ahringer, J.; Mitsch, M.; Maxwell, S.; Woollard, A. (2004). "A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. Elegans". Development. 131 (10): 2373–2385. doi:10.1242/dev.01110. PMID 15102704.
  12. ↑ Ahringer, Julie Ann (1991). Posttranscriptional regulation offem-3, a sex-determining gene of Caenorhabditis elegans (PhD thesis). University of Wisconsin–Madison.
  13. ↑ Ahringer, J.; Rosenquist, T. A.; Lawson, D. N.; Kimble, J. (1992). "The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally". The EMBO Journal. 11 (6): 2303–2310. PMC 556697Freely accessible. PMID 1376249.
  14. ↑ Ahringer, J.; Kimble, J. (1991). "Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region". Nature. 349 (6307): 346–348. doi:10.1038/349346a0. PMID 1702880.
  15. ↑ Malone, C. J.; Misner, L.; Le Bot, N.; Tsai, M. C.; Campbell, J. M.; Ahringer, J.; White, J. G. (2003). "The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus". Cell. 115 (7): 825–836. doi:10.1016/S0092-8674(03)00985-1. PMID 14697201.
  16. ↑ http://www.gurdon.cam.ac.uk/~ahringerlab
  17. ↑ , http://royalsociety.org/events/2004/genes-worms-genetics
  18. ↑ MRC. "Scientific Advisory Board".
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