Immunoconjugate

Immunoconjugates are antibodies conjugated (joined) to a second molecule, usually a toxin, radioisotope or label.^[1]

These conjugates are used in immunotherapy and to develop monoclonal antibody therapy as a targeted form of chemotherapy^[2] when they are often known as antibody-drug conjugates.

When the conjugates include a radioisotope see radioimmunotherapy. When the conjugates include a toxin see immunotoxin.

References

↑ Goldenberg DM, Sharkey RM (2007). "Novel radiolabeled antibody conjugates". Oncogene. 26 (25): 3734–44. doi:10.1038/sj.onc.1210373. PMID 17530026.
↑ Khandare JJ, Minko T (2006). "Antibodies and peptides in cancer therapy". Critical reviews in therapeutic drug carrier systems. 23 (5): 401–35. PMID 17425513.

Further reading

Technology Insight: cytotoxic drug immunoconjugates for cancer therapy. 2007 looks useful from the abstract.
Targeted Therapy of Cancer: New Prospects for Antibodies and Immunoconjugates. 2006 full article, 18 pages.
Arming antibodies: prospects and challenges for immunoconjugates. 2005 10 pages.

This article is issued from Wikipedia - version of the 5/27/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.