INSM1
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Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[3][4][5]
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[5]
Interactions
INSM1 has been shown to interact with SORBS1.[6]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Lan MS, Li Q, Lu J, Modi WS, Notkins AL (Jun 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". J Biol Chem. 269 (19): 14170–4. PMID 8188699.
- ↑ Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (Jun 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". Biochem J. 397 (1): 169–77. doi:10.1042/BJ20051669. PMC 1479746
. PMID 16569215. - 1 2 "Entrez Gene: INSM1 insulinoma-associated 1".
- ↑ Xie, Jingping; Cai Tao; Zhang Honglai; Lan Michael S; Notkins Abner Louis (Jul 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. United States. 80 (1): 54–61. doi:10.1006/geno.2002.6800. ISSN 0888-7543. PMC 1237014. PMID 12079283.
Further reading
- Goto Y, De Silva MG, Toscani A, et al. (1992). "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs.". J. Biol. Chem. 267 (21): 15252–7. PMID 1634555.
- Li Q, Notkins AL, Lan MS (1997). "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1.". Biochem. Biophys. Res. Commun. 236 (3): 776–81. doi:10.1006/bbrc.1997.7054. PMID 9245732.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Breslin MB, Zhu M, Notkins AL, Lan MS (2002). "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.". Nucleic Acids Res. 30 (4): 1038–45. doi:10.1093/nar/30.4.1038. PMC 100352. PMID 11842116.
- Zhu M, Breslin MB, Lan MS (2002). "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.". Pancreas. 24 (2): 139–45. doi:10.1097/00006676-200203000-00004. PMID 11854618.
- Xie J, Cai T, Zhang H, et al. (2003). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.". Genomics. 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.
- Breslin MB, Zhu M, Lan MS (2003). "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.". J. Biol. Chem. 278 (40): 38991–7. doi:10.1074/jbc.M306795200. PMC 1236987. PMID 12890672.
- Tao Zhang; Breslin MB; Lan MS (2009). "Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest.". J. Biol. Chem. 284 (9): 5574–81. doi:10.1074/jbc.M808843200. PMC 2645817. PMID 19124461.
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