HNRPK

HNRNPK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J5K, 1KHM, 1ZZI, 1ZZJ, 1ZZK
Identifiers
Aliases	HNRNPK, CSBP, HNRPK, TUNP, AUKS, heterogeneous nuclear ribonucleoprotein K
External IDs	MGI: 99894 HomoloGene: 81909 GeneCards: HNRNPK
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • nucleic acid binding • DNA binding • RNA binding • poly(A) RNA binding • cadherin binding involved in cell-cell adhesion • single-stranded DNA binding Cellular component • cytoplasm • membrane • focal adhesion • nucleus • catalytic step 2 spliceosome • cell projection • nuclear chromatin • extracellular exosome • nucleoplasm • podosome • spliceosomal complex • intracellular ribonucleoprotein complex • cell junction • extracellular matrix • cell-cell adherens junction Biological process • positive regulation of receptor-mediated endocytosis • regulation of transcription from RNA polymerase II promoter • negative regulation of mRNA splicing, via spliceosome • regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of transcription, DNA-templated • protein sumoylation • transcription, DNA-templated • viral process • regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter • RNA processing • mRNA processing • regulation of low-density lipoprotein particle clearance • positive regulation of low-density lipoprotein particle receptor biosynthetic process • mRNA splicing, via spliceosome • gene expression • signal transduction • positive regulation of transcription from RNA polymerase II promoter • cell-cell adhesion • negative regulation of apoptotic process • RNA splicing • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3190	15387
Ensembl	ENSG00000165119	ENSMUSG00000021546
UniProt	P61978	P61979
RefSeq (mRNA)	NM_002140 NM_031262 NM_031263 NM_001318186 NM_001318187 NM_001318188	NM_001301340 NM_001301341 NM_001301343 NM_001301344 NM_001301345 NM_025279
RefSeq (protein)	NP_002131.2 NP_112552.1 NP_112553.1 NP_001305115.1 NP_001305116.1 NP_001305117.1	NP_001288269.1 NP_001288270.1 NP_001288272.1 NP_001288273.1 NP_001288274.1 NP_079555.1
Location (UCSC)	Chr 9: 83.97 – 83.98 Mb	Chr 13: 58.39 – 58.4 Mb
PubMed search	[1]	[2]
Wikidata

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene.^[3]

Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Multiple alternatively spliced transcript variants have been described for this gene but only three variants have been fully described.^[4]

Interactions

HNRPK has been shown to interact with:

• CSK,^[5]
• DDX1,^[6]
• HNRNPL,^[7]
• KHDRBS1,^[8]
• PCBP2,^[7]
• PRMT1,^[9][10] and
• PTBP1.^[7]

References

Further reading

PDB gallery
1j5k: COMPLEX OF THE KH3 DOMAIN OF HNRNP K WITH A SINGLE_STRANDED 10MER DNA OLIGONUCLEOTIDE  1khm: C-TERMINAL KH DOMAIN OF HNRNP K (KH3)  1zzi: Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA  1zzj: Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA  1zzk: Crystal Structure of the third KH domain of hnRNP K at 0.95A resolution