HLA-B49
| major histocompatibility complex (human), class I, B49 | ||
| Alleles | B*4901, B*4902, B*4903 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*4901 | |
| B*4902 | ||
| B*4903 | ||
| Locus | chr.6 6p21.31 | |
HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50.[1] The serotype identifies the more common HLA-B*50 gene products.[2] (For terminology help see: HLA-serotype tutorial)
Serotype
| B*49 | B49 | B21 | Sample |
| allele | % | % | size (N) |
| 4901 | 94 | 1 | 3002 |
Allele distribution
| freq | ||
| ref. | Population | (%) |
| [4] | Portugal North | 8.7 |
| [4] | Spain Basque Gipuzkoa Province | 6.1 |
| [4] | Madeira | 5.9 |
| [4] | Cameroon Yaounde | 5.4 |
| [4] | Morocco Nador Metalsa (Berber) | 5.1 |
| [4] | Kenya Nandi | 4.6 |
| [4] | Sudanese | 4.3 |
| [4] | Portugal South | 4.1 |
| [4] | Tunisia Tunis | 4.0 |
| [4] | India Jalpaiguri Toto | 3.8 |
| [4] | Senegal Niokholo Mandenka | 3.7 |
| [4] | Uganda Kampala | 3.7 |
| [4] | Spain Eastern Andalusia | 3.5 |
| [4] | Tunisia | 3.5 |
| [4] | Georgia Tibilisi Kurds | 3.4 |
| [4] | Spain Catalonia Girona | 3.4 |
| [4] | Italy North (1) | 3.3 |
| [4] | Cameroon Beti | 3.2 |
| [4] | Israel Ashkenazi and Non Ashkenazi Jews | 3.2 |
| [4] | Guinea Bissau | 3.1 |
| [4] | France South East | 2.7 |
| [4] | Israel Arab Druse | 2.5 |
| [4] | Mali Bandiagara | 2.5 |
| [4] | Jordan Amman | 2.4 |
| [4] | Tunisia Ghannouch | 2.4 |
| [4] | Georgia Tibilisi Georgians | 2.3 |
| [4] | Saudi Arabia Guraiat and Hail | 2.2 |
| [4] | Cameroon Bamileke | 1.9 |
| [4] | Czech Republic | 1.9 |
| [4] | Georgia Svaneti Svans | 1.9 |
| [4] | Macedonia (4) | 1.9 |
| [4] | Bulgaria | 1.8 |
| [4] | Romanian | 1.6 |
| [4] | Italy Bergamo | 1.1 |
| [4] | Zambia Lusaka | 1.1 |
| [4] | Belgium | 1.0 |
| [4] | China North Han | 1.0 |
| [4] | India Andhra Pradesh Golla | 1.0 |
| [4] | Ireland Northern | 1.0 |
| [4] | South Africian Natal Zulu | 1.0 |
References
- ↑ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
- ↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ↑ derived from IMGT/HLA
- 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in
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