HIST1H3I

HIST1H3I
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases HIST1H3I, H3.f, H3/f, H3FF, histone cluster 1, H3i
External IDs MGI: 2448326 HomoloGene: 134496 GeneCards: HIST1H3I
Orthologs
Species Human Mouse
Entrez

8354

319151

Ensembl

ENSG00000275379

ENSMUSG00000069273

UniProt

P68431

Q71DI3
P84228

RefSeq (mRNA)

NM_003533

NM_178205

RefSeq (protein)
Location (UCSC) Chr 6: 27.87 – 27.87 Mb Chr 13: 23.56 – 23.56 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H3.1 is a protein that in humans is encoded by the HIST1H3I gene.[3][4][5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
  4. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. 1 2 "Entrez Gene: HIST1H3I histone cluster 1, H3i".

Further reading

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