HIST1H3C

HIST1H3C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WKJ, 3B95, 2C1J, 3AYW, 3WA9, 3U4S, 5AVB, 2CV5, 5AV5, 3U31, 2UXN, 3AZK, 2C1N, 5C11, 3QO2, 3X1V, 5C13, 4A0J, 4U68, 5AV8, 4LLB, 3U5O, 1O9S, 4FT2, 4HON, 3W99, 3ZVY, 4Z0R, 5AVC, 1CT6, 1Q3L, 3O37, 3W97, 3SOW, 3KMT, 4YM6, 4A7J, 3UEE, 2KWK, 4F4U, 3UEF, 3UIG, 4BD3, 3AZL, 4QBR, 4F56, 3AFA, 4LKA, 5CPK, 5FFV, 3V43, 5CH1, 3U5P, 3AZI, 3U5N, 3AZH, 3UIK, 4QBQ, 1U35, 4UY4, 2OT7, 5AV9, 2B2W, 3U3D, 3AZF, 3W98, 4I51, 4X3K, 4FWF, 2B2T, 2B2V, 4A0N, 2KWJ, 3WAA, 3QJ6, 5DAH, 3AZG, 3AZE, 3X1T, 3RIY, 2L75, 3A1B, 2VPG, 4QBS, 3O35, 5CPJ, 3ZG6, 4YM5, 3AZJ, 2RI7, 3AZN, 3AVR, 5CPI, 2LBM, 3W96, 3O34, 2M0O, 4L7X, 5CH2, 5AV6, 3AZM, 4UP0, 3X1S, 2OX0, 3UII, 3SOU, 4N4H, 4TN7, 1CS9, 3X1U, 4LXL, 2B2U, 2OQ6, 3RIG, 5C3I, 4YHP, 5B24, 5D6Y, 4YHZ, 4Z2M, 5HJD, 5HJC, 5HJB, 5B2I, 5HYN, 5FB0, 5FB1, 5IQL, 5B2J, 5JIN
Identifiers
Aliases	HIST1H3C, H3.1, H3/c, H3FC, histone cluster 1, H3c
External IDs	MGI: 2448355 HomoloGene: 134495 GeneCards: HIST1H3C
Gene ontology Molecular function • DNA binding • histone binding • protein binding • protein heterodimerization activity • cadherin binding involved in cell-cell adhesion Cellular component • nuclear nucleosome • membrane • nucleoplasm • protein complex • chromosome • extracellular region • nuclear chromosome • nucleosome • extracellular exosome • nucleus • nuclear chromosome, telomeric region • cell-cell adherens junction Biological process • telomere organization • cellular protein metabolic process • positive regulation of gene expression, epigenetic • nucleosome assembly • protein heterotetramerization • blood coagulation • DNA replication-dependent nucleosome assembly • regulation of gene silencing • chromatin silencing at rDNA • negative regulation of gene expression, epigenetic • gene silencing by RNA • xenophagy • positive regulation of defense response to virus by host • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8352	15077
Ensembl	ENSG00000278272	ENSMUSG00000093769
UniProt	P68431	Q71DI3
RefSeq (mRNA)	NM_003531	NM_178216
RefSeq (protein)	NP_003520.1 NP_003521.2 NP_003522.1 NP_003523.1 NP_003524.1 NP_003525.1 NP_003526.1 NP_003527.1 NP_003528.1 NP_066298.1	NP_001005464.1 NP_001116847.1 NP_066403.2
Location (UCSC)	Chr 6: 26.05 – 26.05 Mb	Chr 3: 96.25 – 96.25 Mb
PubMed search	[1]	[2]
Wikidata

Histone H3.1 is a protein that in humans is encoded by the HIST1H3C gene.^[3][4][5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[6]

References

Further reading

PDB gallery
1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT  1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION  1f66: 2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z  1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE  1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution  1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution  1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution  1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA  1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA  1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA  1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1s32: Molecular Recognition of the Nucleosomal 'Supergroove'  1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution  1u35: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A  1zbb: Structure of the 4_601_167 Tetranucleosome  1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core  2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione  2cv5: Crystal structure of human nucleosome core particle  2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes  2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element  2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN  2hue: Structure of the H3-H4 chaperone Asf1 bound to histones H3 and H4  2io5: Crystal structure of the CIA- histone H3-H4 complex  2nzd: Nucleosome core particle containing 145 bp of DNA