Growth factor-like domain
| Amyloid precursor N-terminal | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
The GFLD region of amyloid precursor protein | |||||||||
| Identifiers | |||||||||
| Symbol | APP_CU_bd | ||||||||
| Pfam | PF02177 | ||||||||
| InterPro | IPR008154 | ||||||||
| SMART | SM00006 | ||||||||
| SCOP | 1mwp | ||||||||
| SUPERFAMILY | 1mwp | ||||||||
| |||||||||
A growth factor-like domain (GFLD) is a protein domain structurally related to epidermal growth factor, which has a high binding affinity for the epidermal growth factor receptor. As structural domains within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member of the heparin-binding class of GFLDs and may itself have growth factor function, particularly in promoting neuronal development.
References
- Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. (1999). Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6(4):327-31.
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