Glasberg started out writing for animated shows such as Rugrats, Power Rangers, Duckman and Aaahh!!! Real Monsters. Glasberg's credits include Crossing Jordan, The $treet, The Evidence, Bones, Shark and The Mentalist. At the time of his death, he was the writer for NCIS.
Sometime after Glasberg obtained the title of Showrunner for NCIS, he stated that he was a big fan of the M*A*S*H series, and his inspirations from M*A*S*H are occasionally visible within NCIS episodes. For example, the Season 8 episode A Man Walks Into A Bar is inspired by the M*A*S*H episode Dear Sigmund, and the character Dr. Cyril Taft (Jon Cryer) is inspired by Alan Alda's Hawkeye Pierce. Glasberg has also adapted a M*A*S*H tradition in which episodes are formatted as letters from a main character to a loved one. The Season 12 episode House Rules was very reminiscent of the M*A*S*H* episode Dear Dad, and the Season 13 episode Deja Vu was reminiscent of Dear Sigmund.
Glasberg was married to writer Mimi Schmir and had two sons.
Glasberg died in his sleep on September 28, 2016, in Los Angeles at the age of 50.