GRIP1 (gene)

Not to be confused with glucocorticoid receptor-interacting protein 1.

GRIP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2JIL

Identifiers

Aliases

GRIP1, GRIP, glutamate receptor interacting protein 1

External IDs

MGI: 1921303 HomoloGene: 12938 GeneCards: GRIP1

Gene ontology
Molecular function	• beta-catenin binding • transcription coactivator activity • protein C-terminus binding • protein binding • androgen receptor binding • glucocorticoid receptor binding • receptor signaling complex scaffold activity
Cellular component	• recycling endosome • cytosol • postsynaptic membrane • membrane • plasma membrane • synapse • cytoplasmic, membrane-bounded vesicle • cell junction • dendrite • endoplasmic reticulum • membrane raft • neuron projection • cytoplasmic vesicle
Biological process	• protein localization • androgen receptor signaling pathway • intracellular signal transduction • dendrite development • positive regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


23426


74053

Ensembl


ENSG00000155974


ENSMUSG00000034813

UniProt


Q9Y3R0


Q925T6

RefSeq (mRNA)


NM_001178074 NM_021150

NM_001277292 NM_001277293 NM_001277294 NM_001277295 NM_028736
NM_130891 NM_133442

RefSeq (protein)


NP_001171545.1 NP_066973.2

NP_001264221.1 NP_001264223.1 NP_001264224.1 NP_083012.1 NP_570961.1
NP_597699.1

Location (UCSC)

Chr 12: 66.35 – 66.8 Mb

Chr 10: 119.45 – 120.09 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.^[3]^[4]

Interactions

GRIP1 (gene) has been shown to interact with:

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (April 1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron. 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.
↑ "Entrez Gene: GRIP1 glutamate receptor interacting protein 1".
1 2 3 4 5 Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
↑ Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. doi:10.1016/S0896-6273(02)01191-1. PMC 3314502. PMID 12597860.
↑ Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (June 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.

Irvine RA, Ma H, Yu MC, et al. (2000). "Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length.". Hum. Mol. Genet. 9 (2): 267–74. doi:10.1093/hmg/9.2.267. PMID 10607837.
Teyssier C, Belguise K, Galtier F, Chalbos D (2001). "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.". J. Biol. Chem. 276 (39): 36361–9. doi:10.1074/jbc.M101806200. PMID 11477071.
Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.
Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
Braithwaite SP, Xia H, Malenka RC (2002). "Differential roles for NSF and GRIP/ABP in AMPA receptor cycling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7096–101. doi:10.1073/pnas.102156099. PMC 124534. PMID 12011465.
Kotaja N, Karvonen U, Jänne OA, Palvimo JJ (2002). "The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1". J. Biol. Chem. 277 (33): 30283–8. doi:10.1074/jbc.M204768200. PMID 12060666.
Min G, Kim H, Bae Y, et al. (2002). "Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators". J. Biol. Chem. 277 (37): 34626–33. doi:10.1074/jbc.M205239200. PMID 12114525.
Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell. Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
Charych EI, Yu W, Li R, et al. (2004). "A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain". J. Biol. Chem. 279 (37): 38978–90. doi:10.1074/jbc.M405786200. PMID 15226318.
Sugatani J, Nishitani S, Yamakawa K, et al. (2005). "Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1". Mol. Pharmacol. 67 (3): 845–55. doi:10.1124/mol.104.007161. PMID 15557560.
Lin DY, Fang HI, Ma AH, et al. (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMC 533990. PMID 15572661.
Yang CK, Kim JH, Li H, Stallcup MR (2006). "Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97. doi:10.1074/jbc.M510403200. PMC 1626527. PMID 16344550.
Liu PY, Hsieh TY, Chou WY, Huang SM (2006). "Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains". FEBS J. 273 (10): 2172–83. doi:10.1111/j.1742-4658.2006.05231.x. PMID 16649994.
Tsai SJ, Liou YJ, Liao DL, et al. (2007). "No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (3): 752–5. doi:10.1016/j.pnpbp.2007.01.015. PMID 17303296.

PDB gallery

1m5z: The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area

1n7e: Crystal structure of the sixth PDZ domain of GRIP1

1n7f: Crystal structure of the sixth PDZ domain of GRIP1 in complex with liprin C-terminal peptide

1p1d: Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins

1v5q: Solution Structure of the PDZ Domain from Mouse Glutamate Receptor Interacting Protein 1A-L (GRIP1) Homolog

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GRIP1 (gene)

Interactions

References

Further reading